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The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabetes patient...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050290/ https://www.ncbi.nlm.nih.gov/pubmed/33859349 http://dx.doi.org/10.1038/s41598-021-87896-3 |
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author | Kim, Yoo Jin Kim, Tae Gi |
author_facet | Kim, Yoo Jin Kim, Tae Gi |
author_sort | Kim, Yoo Jin |
collection | PubMed |
description | Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabetes patients and 900 (1799 eyes) non-diabetic patients. The endothelial cell density (ECD), variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness (CCT) were analyzed using a noncontact specular microscope and a Pentacam Scheimpflug camera. We also examined the correlation between the corneal parameters and the duration of diabetes. For total ages, the subjects with type 2 diabetes showed significantly lower ECD, hexagonality, higher CV, and thicker CCT than the control group. This difference was more pronounced in patients with long-standing DM (≥ 10 years) and high HbA1c (≥ 7%). When stratified by age group, from the 60 s group, corneal endothelial cell parameters showed a statistically significant difference between DM and control groups. The duration of diabetes was inversely correlated with ECD (r = − 0.167; p = 0.000). These findings suggest that diabetes affects corneal endothelial cell in older age and those with long-standing DM and higher HbA1c. Regular corneal endothelial examinations are required in diabetic patients. |
format | Online Article Text |
id | pubmed-8050290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80502902021-04-16 The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness Kim, Yoo Jin Kim, Tae Gi Sci Rep Article Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabetes patients and 900 (1799 eyes) non-diabetic patients. The endothelial cell density (ECD), variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness (CCT) were analyzed using a noncontact specular microscope and a Pentacam Scheimpflug camera. We also examined the correlation between the corneal parameters and the duration of diabetes. For total ages, the subjects with type 2 diabetes showed significantly lower ECD, hexagonality, higher CV, and thicker CCT than the control group. This difference was more pronounced in patients with long-standing DM (≥ 10 years) and high HbA1c (≥ 7%). When stratified by age group, from the 60 s group, corneal endothelial cell parameters showed a statistically significant difference between DM and control groups. The duration of diabetes was inversely correlated with ECD (r = − 0.167; p = 0.000). These findings suggest that diabetes affects corneal endothelial cell in older age and those with long-standing DM and higher HbA1c. Regular corneal endothelial examinations are required in diabetic patients. Nature Publishing Group UK 2021-04-15 /pmc/articles/PMC8050290/ /pubmed/33859349 http://dx.doi.org/10.1038/s41598-021-87896-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Kim, Yoo Jin Kim, Tae Gi The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
title | The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
title_full | The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
title_fullStr | The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
title_full_unstemmed | The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
title_short | The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
title_sort | effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050290/ https://www.ncbi.nlm.nih.gov/pubmed/33859349 http://dx.doi.org/10.1038/s41598-021-87896-3 |
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