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An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients

The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present a 2D live-cell chamber that approximates the TME a...

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Detalles Bibliográficos
Autores principales:	Gilmore, Anne C., Flaherty, Sarah J., Somasundaram, Veena, Scheiblin, David A., Lockett, Stephen J., Wink, David A., Heinz, William F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050328/ https://www.ncbi.nlm.nih.gov/pubmed/33859337 http://dx.doi.org/10.1038/s42003-021-01954-0

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