Cargando…

A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study

BACKGROUND: The harmonization and standardization of digital medical information for research purposes is a challenging and ongoing collaborative effort. Current research data repositories typically require extensive efforts in harmonizing and transforming original clinical data. The Fast Healthcare...

Descripción completa

Detalles Bibliográficos
Autores principales: Gruendner, Julian, Gulden, Christian, Kampf, Marvin, Mate, Sebastian, Prokosch, Hans-Ulrich, Zierk, Jakob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JMIR Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050750/
https://www.ncbi.nlm.nih.gov/pubmed/33792554
http://dx.doi.org/10.2196/25645
_version_ 1783679632219832320
author Gruendner, Julian
Gulden, Christian
Kampf, Marvin
Mate, Sebastian
Prokosch, Hans-Ulrich
Zierk, Jakob
author_facet Gruendner, Julian
Gulden, Christian
Kampf, Marvin
Mate, Sebastian
Prokosch, Hans-Ulrich
Zierk, Jakob
author_sort Gruendner, Julian
collection PubMed
description BACKGROUND: The harmonization and standardization of digital medical information for research purposes is a challenging and ongoing collaborative effort. Current research data repositories typically require extensive efforts in harmonizing and transforming original clinical data. The Fast Healthcare Interoperability Resources (FHIR) format was designed primarily to represent clinical processes; therefore, it closely resembles the clinical data model and is more widely available across modern electronic health records. However, no common standardized data format is directly suitable for statistical analyses, and data need to be preprocessed before statistical analysis. OBJECTIVE: This study aimed to elucidate how FHIR data can be queried directly with a preprocessing service and be used for statistical analyses. METHODS: We propose that the binary JavaScript Object Notation format of the PostgreSQL (PSQL) open source database is suitable for not only storing FHIR data, but also extending it with preprocessing and filtering services, which directly transform data stored in FHIR format into prepared data subsets for statistical analysis. We specified an interface for this preprocessor, implemented and deployed it at University Hospital Erlangen-Nürnberg, generated 3 sample data sets, and analyzed the available data. RESULTS: We imported real-world patient data from 2016 to 2018 into a standard PSQL database, generating a dataset of approximately 35.5 million FHIR resources, including “Patient,” “Encounter,” “Condition” (diagnoses specified using International Classification of Diseases codes), “Procedure,” and “Observation” (laboratory test results). We then integrated the developed preprocessing service with the PSQL database and the locally installed web-based KETOS analysis platform. Advanced statistical analyses were feasible using the developed framework using 3 clinically relevant scenarios (data-driven establishment of hemoglobin reference intervals, assessment of anemia prevalence in patients with cancer, and investigation of the adverse effects of drugs). CONCLUSIONS: This study shows how the standard open source database PSQL can be used to store FHIR data and be integrated with a specifically developed preprocessing and analysis framework. This enables dataset generation with advanced medical criteria and the integration of subsequent statistical analysis. The web-based preprocessing service can be deployed locally at the hospital level, protecting patients’ privacy while being integrated with existing open source data analysis tools currently being developed across Germany.
format Online
Article
Text
id pubmed-8050750
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher JMIR Publications
record_format MEDLINE/PubMed
spelling pubmed-80507502021-04-22 A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study Gruendner, Julian Gulden, Christian Kampf, Marvin Mate, Sebastian Prokosch, Hans-Ulrich Zierk, Jakob JMIR Med Inform Original Paper BACKGROUND: The harmonization and standardization of digital medical information for research purposes is a challenging and ongoing collaborative effort. Current research data repositories typically require extensive efforts in harmonizing and transforming original clinical data. The Fast Healthcare Interoperability Resources (FHIR) format was designed primarily to represent clinical processes; therefore, it closely resembles the clinical data model and is more widely available across modern electronic health records. However, no common standardized data format is directly suitable for statistical analyses, and data need to be preprocessed before statistical analysis. OBJECTIVE: This study aimed to elucidate how FHIR data can be queried directly with a preprocessing service and be used for statistical analyses. METHODS: We propose that the binary JavaScript Object Notation format of the PostgreSQL (PSQL) open source database is suitable for not only storing FHIR data, but also extending it with preprocessing and filtering services, which directly transform data stored in FHIR format into prepared data subsets for statistical analysis. We specified an interface for this preprocessor, implemented and deployed it at University Hospital Erlangen-Nürnberg, generated 3 sample data sets, and analyzed the available data. RESULTS: We imported real-world patient data from 2016 to 2018 into a standard PSQL database, generating a dataset of approximately 35.5 million FHIR resources, including “Patient,” “Encounter,” “Condition” (diagnoses specified using International Classification of Diseases codes), “Procedure,” and “Observation” (laboratory test results). We then integrated the developed preprocessing service with the PSQL database and the locally installed web-based KETOS analysis platform. Advanced statistical analyses were feasible using the developed framework using 3 clinically relevant scenarios (data-driven establishment of hemoglobin reference intervals, assessment of anemia prevalence in patients with cancer, and investigation of the adverse effects of drugs). CONCLUSIONS: This study shows how the standard open source database PSQL can be used to store FHIR data and be integrated with a specifically developed preprocessing and analysis framework. This enables dataset generation with advanced medical criteria and the integration of subsequent statistical analysis. The web-based preprocessing service can be deployed locally at the hospital level, protecting patients’ privacy while being integrated with existing open source data analysis tools currently being developed across Germany. JMIR Publications 2021-04-01 /pmc/articles/PMC8050750/ /pubmed/33792554 http://dx.doi.org/10.2196/25645 Text en ©Julian Gruendner, Christian Gulden, Marvin Kampf, Sebastian Mate, Hans-Ulrich Prokosch, Jakob Zierk. Originally published in JMIR Medical Informatics (http://medinform.jmir.org), 01.04.2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Medical Informatics, is properly cited. The complete bibliographic information, a link to the original publication on http://medinform.jmir.org/, as well as this copyright and license information must be included.
spellingShingle Original Paper
Gruendner, Julian
Gulden, Christian
Kampf, Marvin
Mate, Sebastian
Prokosch, Hans-Ulrich
Zierk, Jakob
A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study
title A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study
title_full A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study
title_fullStr A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study
title_full_unstemmed A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study
title_short A Framework for Criteria-Based Selection and Processing of Fast Healthcare Interoperability Resources (FHIR) Data for Statistical Analysis: Design and Implementation Study
title_sort framework for criteria-based selection and processing of fast healthcare interoperability resources (fhir) data for statistical analysis: design and implementation study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050750/
https://www.ncbi.nlm.nih.gov/pubmed/33792554
http://dx.doi.org/10.2196/25645
work_keys_str_mv AT gruendnerjulian aframeworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT guldenchristian aframeworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT kampfmarvin aframeworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT matesebastian aframeworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT prokoschhansulrich aframeworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT zierkjakob aframeworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT gruendnerjulian frameworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT guldenchristian frameworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT kampfmarvin frameworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT matesebastian frameworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT prokoschhansulrich frameworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy
AT zierkjakob frameworkforcriteriabasedselectionandprocessingoffasthealthcareinteroperabilityresourcesfhirdataforstatisticalanalysisdesignandimplementationstudy