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An arginine residue in the outer segment of hASIC1a TM1 affects both proton affinity and channel desensitization
Acid-sensing ion channels (ASICs) respond to changes in pH in the central and peripheral nervous systems and participate in synaptic plasticity and pain perception. Understanding the proton-mediated gating mechanism remains elusive despite the of their structures in various conformational states. We...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050794/ https://www.ncbi.nlm.nih.gov/pubmed/33851970 http://dx.doi.org/10.1085/jgp.202012802 |