Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

MED1 (mediator subunit 1)co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice. We observe significantly promoted onset, growth, metastasis...

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Detalles Bibliográficos
Autores principales: Yang, Yongguang, Leonard, Marissa, Luo, Zhenhua, Yeo, Syn, Bick, Gregory, Hao, Mingang, Cai, Chunmiao, Charif, Mahmoud, Wang, Jiang, Guan, Jun-Lin, Lower, Elyse E., Zhang, Xiaoting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050805/
https://www.ncbi.nlm.nih.gov/pubmed/33691110
http://dx.doi.org/10.1016/j.celrep.2021.108822

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