Analysis of single nucleotide polymorphisms in chronic beryllium disease

Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidos...

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Detalles Bibliográficos
Autores principales: Frye, Björn C., Gaede, Karoline I., Saltini, Cesare, Rossman, Milton D., Monos, Dimitri S., Rosenman, Ken D., Schuler, Christine R., Weston, Ainsley, Wegner, Ralf, Noth, Rainer, Zissel, Gernot, Schreiber, Stefan, Nothnagel, Michael, Müller-Quernheim, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051053/
https://www.ncbi.nlm.nih.gov/pubmed/33863318
http://dx.doi.org/10.1186/s12931-021-01691-2
Descripción
Sumario:Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed persons. SNPs were chosen for their relevance in sarcoidosis. Even though one of largest cohorts of beryllium-exposed persons was analysed, no statistically relevant association between any SNP and CBD could be verified. Notably, some SNPs exhibit inverse OR for beryllium sensitization and CBD with nominally statistical significance, which allows hypothesizing about pathophysiological role of genes for the disease triggering and development.

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