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On the role of p53 in the cellular response to aneuploidy

Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. Previous experiments using human cell lines showed that aneuploidy induction leads to p53 accumulation and p21-mediated G1 cell cycle arrest. We find that adherent 2-dimensional (2D) cultures of human...

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Detalles Bibliográficos
Autores principales:	Narkar, Akshay, Johnson, Blake A., Bharne, Pandurang, Zhu, Jin, Padmanaban, Veena, Biswas, Debojyoti, Fraser, Andrew, Iglesias, Pablo A., Ewald, Andrew J., Li, Rong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051136/ https://www.ncbi.nlm.nih.gov/pubmed/33761356 http://dx.doi.org/10.1016/j.celrep.2021.108892

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