Activity and substrate specificity of Candida, Aspergillus, and Coccidioides Tpt1: essential tRNA splicing enzymes and potential antifungal targets

The enzyme Tpt1 is an essential agent of fungal tRNA splicing that removes an internal RNA 2′-PO(4) generated by fungal tRNA ligase. Tpt1 performs a two-step reaction in which: (i) the 2′-PO(4) attacks NAD(+) to form an RNA-2′-phospho-(ADP-ribose) intermediate; and (ii) transesterification of the AD...

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Detalles Bibliográficos
Autores principales: Dantuluri, Swathi, Schwer, Beate, Abdullahu, Leonora, Damha, Masad J., Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051265/
https://www.ncbi.nlm.nih.gov/pubmed/33509912
http://dx.doi.org/10.1261/rna.078660.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051265/
https://www.ncbi.nlm.nih.gov/pubmed/33509912
http://dx.doi.org/10.1261/rna.078660.120

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