Cargando…

Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning

Ethanol is a noncompetitive inhibitor of N-methyl-d-aspartate receptors (NMDARs) and acutely disrupts hippocampal synaptic plasticity and learning. In the present study, we examined the effects of oxysterol positive allosteric modulators (PAMs) of NMDARs on ethanol-mediated inhibition of NMDARs, blo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Izumi, Yukitoshi, Mennerick, Steven J., Doherty, James J., Zorumski, Charles F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2021
Materias:	Neuropharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051516/ https://www.ncbi.nlm.nih.gov/pubmed/33441369 http://dx.doi.org/10.1124/jpet.120.000376

Ejemplares similares

Ethanol Tolerance Affects Endogenous Adenosine Signaling in Mouse Hippocampus
por: Zhang, Dali, et al.
Publicado: (2016)

Task- and Treatment Length–Dependent Effects of Vortioxetine on Scopolamine-Induced Cognitive Dysfunction and Hippocampal Extracellular Acetylcholine in Rats
por: Pehrson, Alan L., et al.
Publicado: (2016)

Adenylyl Cyclase 1 Is Required for Ethanol-Induced Locomotor Sensitization and Associated Increases in NMDA Receptor Phosphorylation and Function in the Dorsal Medial Striatum
por: Bosse, Kelly E., et al.
Publicado: (2017)

Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
por: Wagner, Steven L., et al.
Publicado: (2017)

The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum
por: Boccella, Serena, et al.
Publicado: (2020)

Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice
por: Inyang, Kufreobong E., et al.
Publicado: (2019)

The Nurr1 Ligand,1,1-bis(3′-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism
por: Hammond, Sean L., et al.
Publicado: (2018)

SSRIs differentially modulate the effects of pro-inflammatory stimulation on hippocampal plasticity and memory via sigma 1 receptors and neurosteroids
por: Izumi, Yukitoshi, et al.
Publicado: (2023)

Strain differences in proliferation of progenitor cells in the dentate gyrus of the adult rat and the response to fluoxetine are dependent on corticosterone
por: AlAhmed, S., et al.
Publicado: (2008)

Noncompetitive Inhibition of 5-HT(3) Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling
por: Jarvis, Gavin E., et al.
Publicado: (2016)

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis
por: Svensson, Kjell A., et al.
Publicado: (2017)

Levetiracetam Pharmacokinetics and Brain Uptake in a Lateral Fluid Percussion Injury Rat Model
por: Coles, Lisa D., et al.
Publicado: (2023)

Diverse antiepileptic drugs increase the ratio of background synaptic inhibition to excitation and decrease neuronal excitability in neurones of the rat entorhinal cortex in vitro
por: Greenhill, S.D., et al.
Publicado: (2010)

Limbic system associated membrane protein as a potential target for neuropsychiatric disorders
por: Innos, Jürgen, et al.
Publicado: (2013)

Meet Our Editorial Board Member
por: Fiore, M.
Publicado: (2020)

The Kinetic Component in Drug Discovery: Using the Most Basic Pharmacological Concepts to Advance in Selecting Drugs to Combat CNS Diseases
por: Franco, Rafael, et al.
Publicado: (2020)

An Overview of the Heterogeneity of Major Depressive Disorder: Current Knowledge and Future Prospective
por: Athira, Kaipuzha Venu, et al.
Publicado: (2020)

A Mechanistic Rationale for PDE-4 Inhibitors to Treat Residual Cognitive Deficits in Acquired Brain Injury
por: Schreiber, Rudy, et al.
Publicado: (2020)

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
por: Bagdas, Deniz, et al.
Publicado: (2020)

Animal Galectins and Plant Lectins as Tools for Studies in Neurosciences
por: Araújo, João Ronielly Campêlo, et al.
Publicado: (2020)

The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology
por: Trojan, Ewa, et al.
Publicado: (2020)

Vasopressin & Oxytocin in Control of the Cardiovascular System: An Updated Review
por: Japundžić-Žigon, Nina, et al.
Publicado: (2020)

Meet Our Editorial Board Member
por: Boehm, S.
Publicado: (2020)

Pharmacological Interventions and Rehabilitation Approach for Enhancing Brain Self-repair and Stroke Recovery
por: Szelenberger, Rafał, et al.
Publicado: (2020)

Nimodipine Reappraised: An Old Drug with a Future
por: Carlson, Andrew P., et al.
Publicado: (2020)

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling
por: Liu, Yan, et al.
Publicado: (2020)

Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone
por: Zhang, Leilei, et al.
Publicado: (2020)

Age- and Sex-Specific Plasticity in Dopamine Transporter Function Revealed by Food Restriction and Exercise in a Rat Activity-Based Anorexia Paradigm
por: Gilman, T. Lee, et al.
Publicado: (2019)

Protection from Amyloid β Peptide–Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor
por: Cui, Su-Ying, et al.
Publicado: (2019)

Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis
por: Izumi, Yukitoshi, et al.
Publicado: (2015)

Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo
por: Popiolek, Michael, et al.
Publicado: (2020)

The Endocannabinoid System May Modulate Sleep Disorders in Aging
por: Murillo-Rodríguez, Eric, et al.
Publicado: (2020)

A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons
por: Chen, Daniel M., et al.
Publicado: (2018)

The influence of μ-opioid and noradrenaline reuptake inhibition in the modulation of pain responsive neurones in the central amygdala by tapentadol in rats with neuropathy
por: Gonçalves, Leonor, et al.
Publicado: (2015)

The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling
por: Izumi, Yukitoshi, et al.
Publicado: (2023)

The herbicide glyphosate inhibits hippocampal long-term potentiation and learning through activation of pro-inflammatory signaling
por: Izumi, Yukitoshi, et al.
Publicado: (2023)

Social isolation induces schizophrenia-like behavior potentially associated with HINT1, NMDA receptor 1, and dopamine receptor 2
por: Li, Bai-Jia, et al.
Publicado: (2017)

Modeling Neuronal Diseases in Zebrafish in the Era of CRISPR
por: Espino-Saldaña, Angeles Edith, et al.
Publicado: (2020)

Trigeminal Neuralgia: Basic and Clinical Aspects
por: Araya, Erika Ivanna, et al.
Publicado: (2020)

Meet Our Editorial Board Member
por: Khan, Haroon
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gehfu13pfk0fhgbq64g72e6sjj