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Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm

The coronavirus disease (COVID-19) pandemic has rapidly spread across the globe since its first detection in March 2020. Its widespread manifestations and vascular complications are increasingly being reported even in young and middle-aged patients. Hyperinflammation is a continuum of host's ex...

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Autores principales: Parmar, Jitendra, Patel, Tapan, Shah, Sandip, Kothari, Jay, Dani, Sameer, Vyas, Sagar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051521/
https://www.ncbi.nlm.nih.gov/pubmed/33927903
http://dx.doi.org/10.1155/2021/6696443
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author Parmar, Jitendra
Patel, Tapan
Shah, Sandip
Kothari, Jay
Dani, Sameer
Vyas, Sagar
author_facet Parmar, Jitendra
Patel, Tapan
Shah, Sandip
Kothari, Jay
Dani, Sameer
Vyas, Sagar
author_sort Parmar, Jitendra
collection PubMed
description The coronavirus disease (COVID-19) pandemic has rapidly spread across the globe since its first detection in March 2020. Its widespread manifestations and vascular complications are increasingly being reported even in young and middle-aged patients. Hyperinflammation is a continuum of host's exaggerated inflammatory response representing cytokine dysregulation/storm which produces coagulopathy and vascular endothelial dysfunction, apart from a prothrombotic state. Cytokine storm or direct viral invasion of the vascular endothelial cells through surface angiotensin-converting enzyme 2 receptors may result in endothelial dysfunction which can potentially result in dissection. Only a few case reports have been published in the literature describing vascular dissection without any inciting factors in COVID-19 patients. Herein, we present the first case report of bilateral renal artery dissection in a 41-year-old male patient who recently recovered from COVID-19 and was managed successfully in stages after many medical hurdles.
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spelling pubmed-80515212021-04-28 Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm Parmar, Jitendra Patel, Tapan Shah, Sandip Kothari, Jay Dani, Sameer Vyas, Sagar Case Rep Crit Care Case Report The coronavirus disease (COVID-19) pandemic has rapidly spread across the globe since its first detection in March 2020. Its widespread manifestations and vascular complications are increasingly being reported even in young and middle-aged patients. Hyperinflammation is a continuum of host's exaggerated inflammatory response representing cytokine dysregulation/storm which produces coagulopathy and vascular endothelial dysfunction, apart from a prothrombotic state. Cytokine storm or direct viral invasion of the vascular endothelial cells through surface angiotensin-converting enzyme 2 receptors may result in endothelial dysfunction which can potentially result in dissection. Only a few case reports have been published in the literature describing vascular dissection without any inciting factors in COVID-19 patients. Herein, we present the first case report of bilateral renal artery dissection in a 41-year-old male patient who recently recovered from COVID-19 and was managed successfully in stages after many medical hurdles. Hindawi 2021-04-10 /pmc/articles/PMC8051521/ /pubmed/33927903 http://dx.doi.org/10.1155/2021/6696443 Text en Copyright © 2021 Jitendra Parmar et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Parmar, Jitendra
Patel, Tapan
Shah, Sandip
Kothari, Jay
Dani, Sameer
Vyas, Sagar
Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm
title Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm
title_full Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm
title_fullStr Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm
title_full_unstemmed Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm
title_short Spontaneous Renal Artery Dissection in COVID-19 Pneumonia: Potential Danger of Cytokine Storm
title_sort spontaneous renal artery dissection in covid-19 pneumonia: potential danger of cytokine storm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051521/
https://www.ncbi.nlm.nih.gov/pubmed/33927903
http://dx.doi.org/10.1155/2021/6696443
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