Cargando…
Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 fo...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051524/ https://www.ncbi.nlm.nih.gov/pubmed/33928171 http://dx.doi.org/10.1155/2021/6670960 |
_version_ | 1783679747411148800 |
---|---|
author | Grubic, Zorana Maskalan, Marija Stingl Jankovic, Katarina Burek Kamenaric, Marija Zunec, Renata |
author_facet | Grubic, Zorana Maskalan, Marija Stingl Jankovic, Katarina Burek Kamenaric, Marija Zunec, Renata |
author_sort | Grubic, Zorana |
collection | PubMed |
description | In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 for HLA-DRB1. HLA-A(∗)02:01 (29.5%), B(∗)51:01 (10.5%), C(∗)04:01 (15.8%), and DRB1(∗)16:01 (10.4%) were the most frequent alleles in the Croatian general population. The three most frequent haplotypes were HLA-A(∗)01:01~C(∗)07:01~B(∗)08:01~DRB1(∗)03:01 (4.7%), HLA-A(∗)03:01~C(∗)07:02~B(∗)07:02~DRB1(∗)15:01 (1.7%), and HLA-A(∗)02:01~C(∗)07:01~B(∗)18:01~DRB1(∗)11:04 (1.5%). Allele and haplotype frequencies were compared between national and regional data, and differences were observed, particularly in the North Croatia region. The data has potential use in refining donor recruitment strategies for national registries of volunteer hematopoietic stem cell donors, solid organ allocation schemes, and the design of future disease and anthropological studies. |
format | Online Article Text |
id | pubmed-8051524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-80515242021-04-28 Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation Grubic, Zorana Maskalan, Marija Stingl Jankovic, Katarina Burek Kamenaric, Marija Zunec, Renata J Immunol Res Research Article In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 for HLA-DRB1. HLA-A(∗)02:01 (29.5%), B(∗)51:01 (10.5%), C(∗)04:01 (15.8%), and DRB1(∗)16:01 (10.4%) were the most frequent alleles in the Croatian general population. The three most frequent haplotypes were HLA-A(∗)01:01~C(∗)07:01~B(∗)08:01~DRB1(∗)03:01 (4.7%), HLA-A(∗)03:01~C(∗)07:02~B(∗)07:02~DRB1(∗)15:01 (1.7%), and HLA-A(∗)02:01~C(∗)07:01~B(∗)18:01~DRB1(∗)11:04 (1.5%). Allele and haplotype frequencies were compared between national and regional data, and differences were observed, particularly in the North Croatia region. The data has potential use in refining donor recruitment strategies for national registries of volunteer hematopoietic stem cell donors, solid organ allocation schemes, and the design of future disease and anthropological studies. Hindawi 2021-04-07 /pmc/articles/PMC8051524/ /pubmed/33928171 http://dx.doi.org/10.1155/2021/6670960 Text en Copyright © 2021 Zorana Grubic et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Grubic, Zorana Maskalan, Marija Stingl Jankovic, Katarina Burek Kamenaric, Marija Zunec, Renata Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation |
title | Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation |
title_full | Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation |
title_fullStr | Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation |
title_full_unstemmed | Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation |
title_short | Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation |
title_sort | mapping the human leukocyte antigen diversity among croatian regions: implication in transplantation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051524/ https://www.ncbi.nlm.nih.gov/pubmed/33928171 http://dx.doi.org/10.1155/2021/6670960 |
work_keys_str_mv | AT grubiczorana mappingthehumanleukocyteantigendiversityamongcroatianregionsimplicationintransplantation AT maskalanmarija mappingthehumanleukocyteantigendiversityamongcroatianregionsimplicationintransplantation AT stingljankovickatarina mappingthehumanleukocyteantigendiversityamongcroatianregionsimplicationintransplantation AT burekkamenaricmarija mappingthehumanleukocyteantigendiversityamongcroatianregionsimplicationintransplantation AT zunecrenata mappingthehumanleukocyteantigendiversityamongcroatianregionsimplicationintransplantation |