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Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation

In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 fo...

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Autores principales: Grubic, Zorana, Maskalan, Marija, Stingl Jankovic, Katarina, Burek Kamenaric, Marija, Zunec, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051524/
https://www.ncbi.nlm.nih.gov/pubmed/33928171
http://dx.doi.org/10.1155/2021/6670960
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author Grubic, Zorana
Maskalan, Marija
Stingl Jankovic, Katarina
Burek Kamenaric, Marija
Zunec, Renata
author_facet Grubic, Zorana
Maskalan, Marija
Stingl Jankovic, Katarina
Burek Kamenaric, Marija
Zunec, Renata
author_sort Grubic, Zorana
collection PubMed
description In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 for HLA-DRB1. HLA-A(∗)02:01 (29.5%), B(∗)51:01 (10.5%), C(∗)04:01 (15.8%), and DRB1(∗)16:01 (10.4%) were the most frequent alleles in the Croatian general population. The three most frequent haplotypes were HLA-A(∗)01:01~C(∗)07:01~B(∗)08:01~DRB1(∗)03:01 (4.7%), HLA-A(∗)03:01~C(∗)07:02~B(∗)07:02~DRB1(∗)15:01 (1.7%), and HLA-A(∗)02:01~C(∗)07:01~B(∗)18:01~DRB1(∗)11:04 (1.5%). Allele and haplotype frequencies were compared between national and regional data, and differences were observed, particularly in the North Croatia region. The data has potential use in refining donor recruitment strategies for national registries of volunteer hematopoietic stem cell donors, solid organ allocation schemes, and the design of future disease and anthropological studies.
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spelling pubmed-80515242021-04-28 Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation Grubic, Zorana Maskalan, Marija Stingl Jankovic, Katarina Burek Kamenaric, Marija Zunec, Renata J Immunol Res Research Article In the present study, HLA allele and haplotype frequencies were studied using the HLA data of 9277 Croatian unrelated individuals, typed using high-resolution methods for the HLA-A, -B, -C, and -DRB1 loci. The total numbers of observed alleles were 47 for HLA-A, 88 for HLA-B, 34 for HLA-C, and 53 for HLA-DRB1. HLA-A(∗)02:01 (29.5%), B(∗)51:01 (10.5%), C(∗)04:01 (15.8%), and DRB1(∗)16:01 (10.4%) were the most frequent alleles in the Croatian general population. The three most frequent haplotypes were HLA-A(∗)01:01~C(∗)07:01~B(∗)08:01~DRB1(∗)03:01 (4.7%), HLA-A(∗)03:01~C(∗)07:02~B(∗)07:02~DRB1(∗)15:01 (1.7%), and HLA-A(∗)02:01~C(∗)07:01~B(∗)18:01~DRB1(∗)11:04 (1.5%). Allele and haplotype frequencies were compared between national and regional data, and differences were observed, particularly in the North Croatia region. The data has potential use in refining donor recruitment strategies for national registries of volunteer hematopoietic stem cell donors, solid organ allocation schemes, and the design of future disease and anthropological studies. Hindawi 2021-04-07 /pmc/articles/PMC8051524/ /pubmed/33928171 http://dx.doi.org/10.1155/2021/6670960 Text en Copyright © 2021 Zorana Grubic et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Grubic, Zorana
Maskalan, Marija
Stingl Jankovic, Katarina
Burek Kamenaric, Marija
Zunec, Renata
Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
title Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
title_full Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
title_fullStr Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
title_full_unstemmed Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
title_short Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation
title_sort mapping the human leukocyte antigen diversity among croatian regions: implication in transplantation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051524/
https://www.ncbi.nlm.nih.gov/pubmed/33928171
http://dx.doi.org/10.1155/2021/6670960
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