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An Unexpected Factor to Wellens Syndrome
Factor V Leiden deficiency, the most common inherited thrombophilia, is a risk factor for venous thromboembolism in both the heterozygous and homozygous forms. An autosomal dominant genetic condition, the pattern of incomplete penetrance leads to variable manifestations of the disease. The associati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051553/ https://www.ncbi.nlm.nih.gov/pubmed/33880316 http://dx.doi.org/10.7759/cureus.14489 |
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author | Mohmand, Billal Naqvi, Abeeha Pathmanathan, Anojan Charlamb, Mark |
author_facet | Mohmand, Billal Naqvi, Abeeha Pathmanathan, Anojan Charlamb, Mark |
author_sort | Mohmand, Billal |
collection | PubMed |
description | Factor V Leiden deficiency, the most common inherited thrombophilia, is a risk factor for venous thromboembolism in both the heterozygous and homozygous forms. An autosomal dominant genetic condition, the pattern of incomplete penetrance leads to variable manifestations of the disease. The association with arterial thromboembolism remains controversial, with studies indicating modest increases in risk of coronary artery disease, stroke. We present the case of a 53-year-old male with Wellens syndrome, with a history of heterozygous factor V Leiden deficiency and no other risk factors. Coronary angiography found a complete total occlusion of the proximal left anterior descending artery, with established collaterals, ultimately requiring coronary artery bypass graft. Laboratory testing effectively eliminated the presence of any alternative known risk factors for the advanced coronary artery disease. The literature evaluating a possible link between factor V Leiden deficiency and atherosclerosis remain conflicting. Our case highlights a concerning association and need for further studies. |
format | Online Article Text |
id | pubmed-8051553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-80515532021-04-19 An Unexpected Factor to Wellens Syndrome Mohmand, Billal Naqvi, Abeeha Pathmanathan, Anojan Charlamb, Mark Cureus Cardiology Factor V Leiden deficiency, the most common inherited thrombophilia, is a risk factor for venous thromboembolism in both the heterozygous and homozygous forms. An autosomal dominant genetic condition, the pattern of incomplete penetrance leads to variable manifestations of the disease. The association with arterial thromboembolism remains controversial, with studies indicating modest increases in risk of coronary artery disease, stroke. We present the case of a 53-year-old male with Wellens syndrome, with a history of heterozygous factor V Leiden deficiency and no other risk factors. Coronary angiography found a complete total occlusion of the proximal left anterior descending artery, with established collaterals, ultimately requiring coronary artery bypass graft. Laboratory testing effectively eliminated the presence of any alternative known risk factors for the advanced coronary artery disease. The literature evaluating a possible link between factor V Leiden deficiency and atherosclerosis remain conflicting. Our case highlights a concerning association and need for further studies. Cureus 2021-04-14 /pmc/articles/PMC8051553/ /pubmed/33880316 http://dx.doi.org/10.7759/cureus.14489 Text en Copyright © 2021, Mohmand et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Cardiology Mohmand, Billal Naqvi, Abeeha Pathmanathan, Anojan Charlamb, Mark An Unexpected Factor to Wellens Syndrome |
title | An Unexpected Factor to Wellens Syndrome |
title_full | An Unexpected Factor to Wellens Syndrome |
title_fullStr | An Unexpected Factor to Wellens Syndrome |
title_full_unstemmed | An Unexpected Factor to Wellens Syndrome |
title_short | An Unexpected Factor to Wellens Syndrome |
title_sort | unexpected factor to wellens syndrome |
topic | Cardiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051553/ https://www.ncbi.nlm.nih.gov/pubmed/33880316 http://dx.doi.org/10.7759/cureus.14489 |
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