Cargando…

Loxhd1 Mutations Cause Mechanotransduction Defects in Cochlear Hair Cells

Sound detection happens in the inner ear via the mechanical deflection of the hair bundle of cochlear hair cells. The hair bundle is an apical specialization consisting of actin-filled membrane protrusions (called stereocilia) connected by tip links (TLs) that transfer the deflection force to gate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Trouillet, Alix, Miller, Katharine K., George, Shefin Sam, Wang, Pei, Ali, Noor-E-Seher, Ricci, Anthony, Grillet, Nicolas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051682/ https://www.ncbi.nlm.nih.gov/pubmed/33707295 http://dx.doi.org/10.1523/JNEUROSCI.0975-20.2021

Ejemplares similares

Rat Auditory Inner Hair Cell Mechanotransduction and Stereociliary Membrane Diffusivity Are Similarly Modulated by Calcium
por: George, Shefin S., et al.
Publicado: (2020)

High-resolution immunofluorescence imaging of mouse cochlear hair bundles
por: Miller, Katharine K., et al.
Publicado: (2022)

A two-photon FRAP protocol to measure the stereociliary membrane diffusivity in rat cochlear hair cells
por: George, Shefin S., et al.
Publicado: (2021)

Dimensions of a Living Cochlear Hair Bundle
por: Miller, Katharine K., et al.
Publicado: (2021)

The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells
por: Cunningham, Christopher L, et al.
Publicado: (2017)

Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
por: Wu, Zizhen, et al.
Publicado: (2016)

Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells
por: Corns, Laura F., et al.
Publicado: (2016)

Correction: The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells
por: Cunningham, Christopher L, et al.
Publicado: (2017)

Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells
por: Hu, Qun, et al.
Publicado: (2018)

Mutations in LOXHD1 gene can cause auditory neuropathy spectrum disorder
por: Morlet, T., et al.
Publicado: (2021)

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells
por: Quick, Kathryn, et al.
Publicado: (2012)

The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells
por: Qiu, Xufeng, et al.
Publicado: (2023)

Loxhd1b inhibits the hair cell development in zebrafish: Possible relation to the BDNF/TrkB/ERK pathway
por: Liu, Jingwen, et al.
Publicado: (2022)

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival
por: Michel, Vincent, et al.
Publicado: (2017)

Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1
por: Deng, Qu, et al.
Publicado: (2022)

Missense variant in LOXHD1 is associated with canine nonsyndromic hearing loss
por: Hytönen, Marjo K., et al.
Publicado: (2021)

New Tmc1 Deafness Mutations Impact Mechanotransduction in Auditory Hair Cells
por: Beurg, Maryline, et al.
Publicado: (2021)

Effects of cochlear hair cell ablation on spatial learning/memory
por: Qian, Z. Jason, et al.
Publicado: (2020)

Mutational Spectrum and Clinical Features of Patients with LOXHD1 Variants Identified in an 8074 Hearing Loss Patient Cohort
por: Maekawa, Karuna, et al.
Publicado: (2019)

A novel LOXHD1 variant in a Chinese couple with hearing loss
por: Zhang, Chuan, et al.
Publicado: (2019)

Identifying components of the hair-cell interactome involved in cochlear amplification
por: Zheng, Jing, et al.
Publicado: (2009)

TRPV6, TRPM6 and TRPM7 Do Not Contribute to Hair-Cell Mechanotransduction
por: Morgan, Clive P., et al.
Publicado: (2018)

Cell biology of mechanotransduction in inner-ear hair cells
por: Corey, David P
Publicado: (2009)

Kinematics Governing Mechanotransduction in the Sensory Hair of the Venus flytrap
por: Saikia, Eashan, et al.
Publicado: (2020)

High-resolution imaging of the mouse-hair-cell hair bundle by scanning electron microscopy
por: Grillet, Nicolas
Publicado: (2022)

Genetic Analysis of the LOXHD1 Gene in Chinese Patients With Non-Syndromic Hearing Loss
por: Wang, Wei-Qian, et al.
Publicado: (2022)

Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice
por: Wu, Xudong, et al.
Publicado: (2016)

The Development of Cooperative Channels Explains the Maturation of Hair Cell’s Mechanotransduction
por: Gianoli, Francesco, et al.
Publicado: (2019)

Underestimated Sensitivity of Mammalian Cochlear Hair Cells Due to Splay between Stereociliary Columns
por: Nam, Jong-Hoon, et al.
Publicado: (2015)

Mutations in Protocadherin 15 and Cadherin 23 Affect Tip Links and Mechanotransduction in Mammalian Sensory Hair Cells
por: Alagramam, Kumar N., et al.
Publicado: (2011)

Five Novel Mutations in LOXHD1 Gene Were Identified to Cause Autosomal Recessive Nonsyndromic Hearing Loss in Four Chinese Families
por: Bai, Xiaohui, et al.
Publicado: (2020)

Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex
por: Li, Sihan, et al.
Publicado: (2020)

Corrigendum to “Five Novel Mutations in LOXHD1 Gene Were Identified to Cause Autosomal Recessive Nonsyndromic Hearing Loss in Four Chinese Families”
por: Bai, Xiaohui, et al.
Publicado: (2020)

HCN Channels Are Not Required for Mechanotransduction in Sensory Hair Cells of the Mouse Inner Ear
por: Horwitz, Geoffrey C., et al.
Publicado: (2010)

Mechanotransduction current is essential for stability of the transducing stereocilia in mammalian auditory hair cells
por: Vélez-Ortega, A Catalina, et al.
Publicado: (2017)

Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
por: Schmid, Caleigh, et al.
Publicado: (2020)

Differential expression of mechanotransduction complex genes in auditory/vestibular hair cells in zebrafish
por: Smith, Eliot T., et al.
Publicado: (2023)

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
por: Baeyens, Nicolas, et al.
Publicado: (2016)

Cochlear hair cell densities in the rabbit
por: Yuan, Fang, et al.
Publicado: (2018)

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
por: Corns, Laura F., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_k30hndiaor5vgleh13gt3lfe0j