Cargando…

Down‐regulation of RCC1 sensitizes immunotherapy by up‐regulating PD‐L1 via p27(kip1)/CDK4 axis in non‐small cell lung cancer

In recent years, although Immune Checkpoint Inhibitors (ICIs) significantly improves survival both in local advanced stage and advanced stage of non‐small cell lung cancer (NSCLC), the objective response rate of ICI monotherapy is still only about 20%. Thus, to identify the mechanisms of ICI resista...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zeng, Xiaozhu, Zhong, Maoxi, Yang, Yumeng, Wang, Zhi, Zhu, Yuxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051708/ https://www.ncbi.nlm.nih.gov/pubmed/33630417 http://dx.doi.org/10.1111/jcmm.16383

Ejemplares similares

PD-1/PD-L1 Inhibitors versus Chemotherapy for Previously Treated Advanced Gastroesophageal Cancer: A Meta-Analysis of Randomized Controlled Trials
por: Maoxi, Zhong, et al.
Publicado: (2021)

Regulation of p27(Kip1) and p57(Kip2) Functions by Natural Polyphenols
por: Russo, Gian Luigi, et al.
Publicado: (2020)

p27(Kip1) regulates alpha-synuclein expression
por: Gallastegui, Edurne, et al.
Publicado: (2018)

Role of p27(Kip1) as a transcriptional regulator
por: Bachs, Oriol, et al.
Publicado: (2018)

p27(Kip1) and p21(Cip1) collaborate in the regulation of transcription by recruiting cyclin–Cdk complexes on the promoters of target genes
por: Orlando, Serena, et al.
Publicado: (2015)

Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27(Kip1)
por: Wang, Shuo, et al.
Publicado: (2008)

Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27(Kip1)
por: Guo, Xueyan, et al.
Publicado: (2011)

NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation
por: Tang, Hao, et al.
Publicado: (2015)

The AMPK/p27(Kip1) Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
por: White, James P., et al.
Publicado: (2018)

PCK1 negatively regulates cell cycle progression and hepatoma cell proliferation via the AMPK/p27(Kip1) axis
por: Tuo, Lin, et al.
Publicado: (2019)

p27(Kip1) and Ser10-phosphorylated p27(Kip1) in breast cancer: clinical significance and expression
por: Song, Wei, et al.
Publicado: (2015)

A p27(Kip1) mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation
por: Sharma, S S, et al.
Publicado: (2012)

Role of T198 Modification in the Regulation of p27(Kip1) Protein Stability and Function
por: Schiappacassi, Monica, et al.
Publicado: (2011)

Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6
por: Deshmukh, Dhanraj, et al.
Publicado: (2022)

PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27(Kip1)
por: Pérez-Luna, Maria, et al.
Publicado: (2012)

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
por: Rowland, Rhianna J., et al.
Publicado: (2023)

Up‐regulation of cofilin‐1 in cell senescence associates with morphological change and p27(kip1)‐mediated growth delay
por: Tsai, Cheng‐Han, et al.
Publicado: (2020)

p27(Kip1) participates in the regulation of endoreplication in differentiating chick retinal ganglion cells
por: Ovejero-Benito, María C, et al.
Publicado: (2015)

Mutation of the Cell Cycle Regulator p27kip1 Drives Pseudohypoxic Pheochromocytoma Development
por: Mohr, Hermine, et al.
Publicado: (2021)

A new tumour suppression mechanism by p27(Kip1): EGFR down-regulation mediated by JNK/c-Jun pathway inhibition
por: Fang, Yong, et al.
Publicado: (2014)

Partial hepatectomy in rats results in immediate down-regulation of p27Kip1 in residual liver tissue by transcriptional and post-translational processes
por: Rohlfing, Anne-Katrin, et al.
Publicado: (2013)

p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
por: Jeannot, Pauline, et al.
Publicado: (2017)

Up‐regulation of p27(Kip1) Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines
por: Kawada, Manabu, et al.
Publicado: (1998)

Editor's Note on ‘PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27(Kip1)’
Publicado: (2023)

p27(kip1): a target for tumor therapies?
por: Nickeleit, Irina, et al.
Publicado: (2007)

Phosphorylation and Subcellular Localization of p27Kip1 Regulated by Hydrogen Peroxide Modulation in Cancer Cells
por: Ibañez, Irene L., et al.
Publicado: (2012)

T Cell-Intrinsic and Extrinsic Mechanisms of p27(Kip1) in the Regulation of CD8 T Cell Memory
por: Jatzek, Anna, et al.
Publicado: (2012)

Brachyury regulates proliferation of cancer cells via a p27(Kip1-)dependent pathway
por: Jezkova, Jana, et al.
Publicado: (2014)

Loss of p27(Kip1) promotes metaplasia in the pancreas via the regulation of Sox9 expression
por: Jeannot, Pauline, et al.
Publicado: (2015)

PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27(Kip1)
por: Nicholas, Courtney, et al.
Publicado: (2013)

p27(Kip1), PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes
por: Perearnau, Anna, et al.
Publicado: (2017)

GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27(kip1)
por: Xu, Jiadong, et al.
Publicado: (2021)

CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation
por: Galardi, Silvia, et al.
Publicado: (2016)

Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 (Kip1) axis
por: Liu, Hui, et al.
Publicado: (2018)

CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis
por: Zhang, Shu, et al.
Publicado: (2015)

EpoR Activation Stimulates Erythroid Precursor Proliferation by Inducing Phosphorylation of Tyrosine-88 of the CDK-Inhibitor p27(Kip1)
por: Pegka, Fragka, et al.
Publicado: (2023)

Down-Regulation of TMPO-AS1 Induces Apoptosis in Lung Carcinoma Cells by Regulating miR-143-3p/CDK1 Axis
por: Li, Qiu, et al.
Publicado: (2021)

The Akt/FoxO/p27(Kip1) axis contributes to the anti‐proliferation of pentoxifylline in hypertrophic scars
por: Yang, Fangfang, et al.
Publicado: (2019)

Immunohistochemical Expression of p27(Kip1), p57(Kip2), Cyclin D1, Nestin, and Ki-67 in Ependymoma
por: Iqneibi, Shahad, et al.
Publicado: (2022)

MicroRNA-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27(Kip1)
por: Hou, T, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_pps2bp3jlch03pcq5eafk64rl4