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CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients

OBJECTIVE: Obesity is a negative prognostic factor for various clinical conditions. In this observational cohort study, we evaluated a CT-based assessment of the adipose tissue distribution as a potential non-invasive prognostic parameter in critical illness. METHODS: Routine CT-scans upon admission...

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Autores principales: Wirtz, Theresa H., Loosen, Sven H., Schulze-Hagen, Maximilian, Weiskirchen, Ralf, Buendgens, Lukas, Abu Jhaisha, Samira, Brozat, Jonathan F., Puengel, Tobias, Vucur, Mihael, Paffenholz, Pia, Kuhl, Christiane, Tacke, Frank, Trautwein, Christian, Luedde, Tom, Roderburg, Christoph, Koch, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051769/
https://www.ncbi.nlm.nih.gov/pubmed/33861804
http://dx.doi.org/10.1371/journal.pone.0250321
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author Wirtz, Theresa H.
Loosen, Sven H.
Schulze-Hagen, Maximilian
Weiskirchen, Ralf
Buendgens, Lukas
Abu Jhaisha, Samira
Brozat, Jonathan F.
Puengel, Tobias
Vucur, Mihael
Paffenholz, Pia
Kuhl, Christiane
Tacke, Frank
Trautwein, Christian
Luedde, Tom
Roderburg, Christoph
Koch, Alexander
author_facet Wirtz, Theresa H.
Loosen, Sven H.
Schulze-Hagen, Maximilian
Weiskirchen, Ralf
Buendgens, Lukas
Abu Jhaisha, Samira
Brozat, Jonathan F.
Puengel, Tobias
Vucur, Mihael
Paffenholz, Pia
Kuhl, Christiane
Tacke, Frank
Trautwein, Christian
Luedde, Tom
Roderburg, Christoph
Koch, Alexander
author_sort Wirtz, Theresa H.
collection PubMed
description OBJECTIVE: Obesity is a negative prognostic factor for various clinical conditions. In this observational cohort study, we evaluated a CT-based assessment of the adipose tissue distribution as a potential non-invasive prognostic parameter in critical illness. METHODS: Routine CT-scans upon admission to the intensive care unit (ICU) were used to analyze the visceral and subcutaneous adipose tissue areas at the 3(rd) lumbar vertebra in 155 patients. Results were correlated with various prognostic markers and both short-term- and overall survival. Multiple statistical tools were used for data analysis. RESULTS: We observed a significantly larger visceral adipose tissue area in septic patients compared to non-sepsis patients. Interestingly, patients requiring mechanical ventilation had a significantly higher amount of visceral adipose tissue correlating with the duration of mechanical ventilation. Moreover, both visceral and subcutaneous adipose tissue area significantly correlated with several laboratory markers. While neither the visceral nor the subcutaneous adipose tissue area was predictive for short-term ICU survival, patients with a visceral adipose tissue area above the optimal cut-off (241.4 cm(2)) had a significantly impaired overall survival compared to patients with a lower visceral adipose tissue area. CONCLUSIONS: Our study supports a prognostic role of the individual adipose tissue distribution in critically ill patients. However, additional investigations need to confirm our suggestion that routine CT-based assessment of adipose tissue distribution can be used to yield further information on the patients’ clinical course. Moreover, future studies should address functional and metabolic analysis of different adipose tissue compartments in critical illness.
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spelling pubmed-80517692021-04-28 CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients Wirtz, Theresa H. Loosen, Sven H. Schulze-Hagen, Maximilian Weiskirchen, Ralf Buendgens, Lukas Abu Jhaisha, Samira Brozat, Jonathan F. Puengel, Tobias Vucur, Mihael Paffenholz, Pia Kuhl, Christiane Tacke, Frank Trautwein, Christian Luedde, Tom Roderburg, Christoph Koch, Alexander PLoS One Research Article OBJECTIVE: Obesity is a negative prognostic factor for various clinical conditions. In this observational cohort study, we evaluated a CT-based assessment of the adipose tissue distribution as a potential non-invasive prognostic parameter in critical illness. METHODS: Routine CT-scans upon admission to the intensive care unit (ICU) were used to analyze the visceral and subcutaneous adipose tissue areas at the 3(rd) lumbar vertebra in 155 patients. Results were correlated with various prognostic markers and both short-term- and overall survival. Multiple statistical tools were used for data analysis. RESULTS: We observed a significantly larger visceral adipose tissue area in septic patients compared to non-sepsis patients. Interestingly, patients requiring mechanical ventilation had a significantly higher amount of visceral adipose tissue correlating with the duration of mechanical ventilation. Moreover, both visceral and subcutaneous adipose tissue area significantly correlated with several laboratory markers. While neither the visceral nor the subcutaneous adipose tissue area was predictive for short-term ICU survival, patients with a visceral adipose tissue area above the optimal cut-off (241.4 cm(2)) had a significantly impaired overall survival compared to patients with a lower visceral adipose tissue area. CONCLUSIONS: Our study supports a prognostic role of the individual adipose tissue distribution in critically ill patients. However, additional investigations need to confirm our suggestion that routine CT-based assessment of adipose tissue distribution can be used to yield further information on the patients’ clinical course. Moreover, future studies should address functional and metabolic analysis of different adipose tissue compartments in critical illness. Public Library of Science 2021-04-16 /pmc/articles/PMC8051769/ /pubmed/33861804 http://dx.doi.org/10.1371/journal.pone.0250321 Text en © 2021 Wirtz et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Wirtz, Theresa H.
Loosen, Sven H.
Schulze-Hagen, Maximilian
Weiskirchen, Ralf
Buendgens, Lukas
Abu Jhaisha, Samira
Brozat, Jonathan F.
Puengel, Tobias
Vucur, Mihael
Paffenholz, Pia
Kuhl, Christiane
Tacke, Frank
Trautwein, Christian
Luedde, Tom
Roderburg, Christoph
Koch, Alexander
CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
title CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
title_full CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
title_fullStr CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
title_full_unstemmed CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
title_short CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
title_sort ct-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051769/
https://www.ncbi.nlm.nih.gov/pubmed/33861804
http://dx.doi.org/10.1371/journal.pone.0250321
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