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Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer’s disease pathologies

Netrin-1, a family member of laminin-related secreted proteins, mediates axon guidance and cell migration during neural development. T835M mutation in netrin receptor UNC5C predisposes to the late-onset Alzheimer’s disease (AD) and increases neuronal cell death. However, it remains unclear how this...

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Detalles Bibliográficos
Autores principales:	Chen, Guiqin, Kang, Seong Su, Wang, Zhihao, Ahn, Eun Hee, Xia, Yiyuan, Liu, Xia, Sandoval, Ivette M., Manfredsson, Fredric P., Zhang, Zhaohui, Ye, Keqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051868/ https://www.ncbi.nlm.nih.gov/pubmed/33863723 http://dx.doi.org/10.1126/sciadv.abe4499

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