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Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex

The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a hippocampal output recipient layer Vb and a cortical projecting layer Va. With th...

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Autores principales: Ohara, Shinya, Blankvoort, Stefan, Nair, Rajeevkumar Raveendran, Nigro, Maximiliano J, Nilssen, Eirik S, Kentros, Clifford, Witter, Menno P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051944/
https://www.ncbi.nlm.nih.gov/pubmed/33769282
http://dx.doi.org/10.7554/eLife.67262
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author Ohara, Shinya
Blankvoort, Stefan
Nair, Rajeevkumar Raveendran
Nigro, Maximiliano J
Nilssen, Eirik S
Kentros, Clifford
Witter, Menno P
author_facet Ohara, Shinya
Blankvoort, Stefan
Nair, Rajeevkumar Raveendran
Nigro, Maximiliano J
Nilssen, Eirik S
Kentros, Clifford
Witter, Menno P
author_sort Ohara, Shinya
collection PubMed
description The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a hippocampal output recipient layer Vb and a cortical projecting layer Va. With the use of in vitro electrophysiology in transgenic mice specific for layer Vb, we assessed the presence of the thus necessary connection from layer Vb-to-Va in the functionally distinct medial (MEC) and lateral (LEC) subdivisions; MEC, particularly its dorsal part, processes allocentric spatial information, whereas the corresponding part of LEC processes information representing elements of episodes. Using identical experimental approaches, we show that connections from layer Vb-to-Va neurons are stronger in dorsal LEC compared with dorsal MEC, suggesting different operating principles in these two regions. Although further in vivo experiments are needed, our findings imply a potential difference in how LEC and MEC mediate episodic systems consolidation.
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spelling pubmed-80519442021-04-21 Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex Ohara, Shinya Blankvoort, Stefan Nair, Rajeevkumar Raveendran Nigro, Maximiliano J Nilssen, Eirik S Kentros, Clifford Witter, Menno P eLife Neuroscience The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a hippocampal output recipient layer Vb and a cortical projecting layer Va. With the use of in vitro electrophysiology in transgenic mice specific for layer Vb, we assessed the presence of the thus necessary connection from layer Vb-to-Va in the functionally distinct medial (MEC) and lateral (LEC) subdivisions; MEC, particularly its dorsal part, processes allocentric spatial information, whereas the corresponding part of LEC processes information representing elements of episodes. Using identical experimental approaches, we show that connections from layer Vb-to-Va neurons are stronger in dorsal LEC compared with dorsal MEC, suggesting different operating principles in these two regions. Although further in vivo experiments are needed, our findings imply a potential difference in how LEC and MEC mediate episodic systems consolidation. eLife Sciences Publications, Ltd 2021-03-26 /pmc/articles/PMC8051944/ /pubmed/33769282 http://dx.doi.org/10.7554/eLife.67262 Text en © 2021, Ohara et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Ohara, Shinya
Blankvoort, Stefan
Nair, Rajeevkumar Raveendran
Nigro, Maximiliano J
Nilssen, Eirik S
Kentros, Clifford
Witter, Menno P
Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
title Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
title_full Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
title_fullStr Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
title_full_unstemmed Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
title_short Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
title_sort local projections of layer vb-to-va are more prominent in lateral than in medial entorhinal cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051944/
https://www.ncbi.nlm.nih.gov/pubmed/33769282
http://dx.doi.org/10.7554/eLife.67262
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