Cargando…

The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan

BACKGROUND: (68)Ga-PSMA-PET/CT (positron emission tomography/computed tomography) is a promising method for prostate cancer (PC) detection. However, the ability of (68)Ga-PSMA-PET/CT to detect malignant bone lesions, and whether this method is superior to the existing bone imaging methods are still...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Ruining, Li, Yajie, Nie, Lihong, Qin, Kaiyue, Zhang, Hang, Shi, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052000/
https://www.ncbi.nlm.nih.gov/pubmed/33847640
http://dx.doi.org/10.1097/MD.0000000000025417
_version_ 1783679845378555904
author Zhao, Ruining
Li, Yajie
Nie, Lihong
Qin, Kaiyue
Zhang, Hang
Shi, Hongbin
author_facet Zhao, Ruining
Li, Yajie
Nie, Lihong
Qin, Kaiyue
Zhang, Hang
Shi, Hongbin
author_sort Zhao, Ruining
collection PubMed
description BACKGROUND: (68)Ga-PSMA-PET/CT (positron emission tomography/computed tomography) is a promising method for prostate cancer (PC) detection. However, the ability of (68)Ga-PSMA-PET/CT to detect malignant bone lesions, and whether this method is superior to the existing bone imaging methods are still lack of systematic analysis. PURPOSE: To evaluate the value of (68)Ga-PSMA-PET/CT and bone scan in clinical diagnosis of prostatic cancer from the perspective of evidence-based medicine. METHODS: PubMed, The Cochrane Library, EMBASE, Springer Link, Sinomed, CNKI, Wanfang database, and CQVIP database were searched to find the satisfactory studies that needed systematic review of trials and compared the value of 68Ga-PSMA-PET/CT and bone scan. All studies published from inception to March 31, 2020. According to the inclusion and exclusion criteria, 2 reviewers independently evaluated and extracted the literature. Review Manager 5.3 was applied to evaluate the included literature quality. The heterogeneity of the included literature was tested by Meta Disc 1.4, and the effect model was selected according to the heterogeneity test results, and the sensitivity (SEN), specificity (SPE), PLR, NLR and diagnostic odds ratio (DOR) were analyzed. After testing the heterogeneity results of literature by using the 95% confidence interval and the forest map. RESULTS: A total of 4 studies were eligible for inclusion in the meta-analysis, which included 318 patients, 120 cases with bone metastasis and 198 cases without bone metastasis. The results of summary evaluation for (68)Ga-PSMA-PET/CT and bone scan in diagnosis of prostatic cancer as follow respectively: The SEN were 0.97 and 0.86; the SPE were 1.00 and 0.87; the DOR were 1468.33 and 36.23; PLR were 88.45 and 6.67; NLR were 0.05 and 0.19; and the area under curve (AUC) and 95% CI were 0.9973 (1.0000–0.9927) and 0.8838 (0.9584–0.8092). CONCLUSION: By comparing the diagnostic results of (68)Ga-PSMA-PET/CT and bone scan imaging diagnosis methods, the (68)Ga-PSMA-PET/CT has a higher SEN and SPE than bone scan, and it has a higher diagnostic efficiency for prostate cancer bone metastasis, which is worthy of clinical application.
format Online
Article
Text
id pubmed-8052000
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-80520002021-04-19 The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan Zhao, Ruining Li, Yajie Nie, Lihong Qin, Kaiyue Zhang, Hang Shi, Hongbin Medicine (Baltimore) 7300 BACKGROUND: (68)Ga-PSMA-PET/CT (positron emission tomography/computed tomography) is a promising method for prostate cancer (PC) detection. However, the ability of (68)Ga-PSMA-PET/CT to detect malignant bone lesions, and whether this method is superior to the existing bone imaging methods are still lack of systematic analysis. PURPOSE: To evaluate the value of (68)Ga-PSMA-PET/CT and bone scan in clinical diagnosis of prostatic cancer from the perspective of evidence-based medicine. METHODS: PubMed, The Cochrane Library, EMBASE, Springer Link, Sinomed, CNKI, Wanfang database, and CQVIP database were searched to find the satisfactory studies that needed systematic review of trials and compared the value of 68Ga-PSMA-PET/CT and bone scan. All studies published from inception to March 31, 2020. According to the inclusion and exclusion criteria, 2 reviewers independently evaluated and extracted the literature. Review Manager 5.3 was applied to evaluate the included literature quality. The heterogeneity of the included literature was tested by Meta Disc 1.4, and the effect model was selected according to the heterogeneity test results, and the sensitivity (SEN), specificity (SPE), PLR, NLR and diagnostic odds ratio (DOR) were analyzed. After testing the heterogeneity results of literature by using the 95% confidence interval and the forest map. RESULTS: A total of 4 studies were eligible for inclusion in the meta-analysis, which included 318 patients, 120 cases with bone metastasis and 198 cases without bone metastasis. The results of summary evaluation for (68)Ga-PSMA-PET/CT and bone scan in diagnosis of prostatic cancer as follow respectively: The SEN were 0.97 and 0.86; the SPE were 1.00 and 0.87; the DOR were 1468.33 and 36.23; PLR were 88.45 and 6.67; NLR were 0.05 and 0.19; and the area under curve (AUC) and 95% CI were 0.9973 (1.0000–0.9927) and 0.8838 (0.9584–0.8092). CONCLUSION: By comparing the diagnostic results of (68)Ga-PSMA-PET/CT and bone scan imaging diagnosis methods, the (68)Ga-PSMA-PET/CT has a higher SEN and SPE than bone scan, and it has a higher diagnostic efficiency for prostate cancer bone metastasis, which is worthy of clinical application. Lippincott Williams & Wilkins 2021-04-16 /pmc/articles/PMC8052000/ /pubmed/33847640 http://dx.doi.org/10.1097/MD.0000000000025417 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 7300
Zhao, Ruining
Li, Yajie
Nie, Lihong
Qin, Kaiyue
Zhang, Hang
Shi, Hongbin
The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan
title The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan
title_full The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan
title_fullStr The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan
title_full_unstemmed The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan
title_short The meta-analysis of the effect of (68)Ga-PSMA-PET/CT diagnosis of prostatic cancer compared with bone scan
title_sort meta-analysis of the effect of (68)ga-psma-pet/ct diagnosis of prostatic cancer compared with bone scan
topic 7300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052000/
https://www.ncbi.nlm.nih.gov/pubmed/33847640
http://dx.doi.org/10.1097/MD.0000000000025417
work_keys_str_mv AT zhaoruining themetaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT liyajie themetaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT nielihong themetaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT qinkaiyue themetaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT zhanghang themetaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT shihongbin themetaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT zhaoruining metaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT liyajie metaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT nielihong metaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT qinkaiyue metaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT zhanghang metaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan
AT shihongbin metaanalysisoftheeffectof68gapsmapetctdiagnosisofprostaticcancercomparedwithbonescan