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Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study
Previous studies showed that microRNA (miR)-449a may function as a tumor suppressor. However, the expression pattern and value of circulating miR-449a in colorectal cancer (CRC) remain unclear. Therefore, the purpose of this study was to measure circulating miR-449a level of CRC patients and evaluat...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052019/ https://www.ncbi.nlm.nih.gov/pubmed/33847612 http://dx.doi.org/10.1097/MD.0000000000025022 |
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author | Fu, Dengke Chen, Yang Xu, Dongkui |
author_facet | Fu, Dengke Chen, Yang Xu, Dongkui |
author_sort | Fu, Dengke |
collection | PubMed |
description | Previous studies showed that microRNA (miR)-449a may function as a tumor suppressor. However, the expression pattern and value of circulating miR-449a in colorectal cancer (CRC) remain unclear. Therefore, the purpose of this study was to measure circulating miR-449a level of CRC patients and evaluate its value for predicting prognosis. Plasma samples of 343 consecutive CRC patients and 162 healthy controls were obtained. Circulating miR-449a levels were measured by using real-time quantitative reverse transcription polymerase chain reactions. All enrolled patients were followed up in a regular interval after surgery. The clinical data and survival outcome of all 343 patients were collected. The correlation between circulating miR-449a level and survival outcomes was analyzed by univariate and multivariate analysis. Circulating miR-449a level in CRC patients was significantly decreased (P < .05) comparing with healthy controls. Low miR-449a was significantly associated with CEA and CA19-9 level (both P < .05). Furthermore, patients with a decreased miR-449a level had a lower 5-years overall survival (OS) rate than those with a high miR-449a (67.4% vs 76.9%, P = .03). Low circulating miR-449a level also been demonstrated as an independent risk factor for CRC in multivariate COX analysis (HR, 2.56; 95%CI: 1.15–8.63; P < .05). Circulating miR-449a was significantly decreased in CRC patients and closely related to poor prognosis, suggesting that miR-449a might can be used as a useful diagnostic and prognostic marker for CRC. |
format | Online Article Text |
id | pubmed-8052019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-80520192021-04-19 Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study Fu, Dengke Chen, Yang Xu, Dongkui Medicine (Baltimore) 5700 Previous studies showed that microRNA (miR)-449a may function as a tumor suppressor. However, the expression pattern and value of circulating miR-449a in colorectal cancer (CRC) remain unclear. Therefore, the purpose of this study was to measure circulating miR-449a level of CRC patients and evaluate its value for predicting prognosis. Plasma samples of 343 consecutive CRC patients and 162 healthy controls were obtained. Circulating miR-449a levels were measured by using real-time quantitative reverse transcription polymerase chain reactions. All enrolled patients were followed up in a regular interval after surgery. The clinical data and survival outcome of all 343 patients were collected. The correlation between circulating miR-449a level and survival outcomes was analyzed by univariate and multivariate analysis. Circulating miR-449a level in CRC patients was significantly decreased (P < .05) comparing with healthy controls. Low miR-449a was significantly associated with CEA and CA19-9 level (both P < .05). Furthermore, patients with a decreased miR-449a level had a lower 5-years overall survival (OS) rate than those with a high miR-449a (67.4% vs 76.9%, P = .03). Low circulating miR-449a level also been demonstrated as an independent risk factor for CRC in multivariate COX analysis (HR, 2.56; 95%CI: 1.15–8.63; P < .05). Circulating miR-449a was significantly decreased in CRC patients and closely related to poor prognosis, suggesting that miR-449a might can be used as a useful diagnostic and prognostic marker for CRC. Lippincott Williams & Wilkins 2021-04-16 /pmc/articles/PMC8052019/ /pubmed/33847612 http://dx.doi.org/10.1097/MD.0000000000025022 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 5700 Fu, Dengke Chen, Yang Xu, Dongkui Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study |
title | Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study |
title_full | Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study |
title_fullStr | Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study |
title_full_unstemmed | Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study |
title_short | Circulating miR-449a predicts survival outcome for colorectal cancer following curative resection: An observational study |
title_sort | circulating mir-449a predicts survival outcome for colorectal cancer following curative resection: an observational study |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052019/ https://www.ncbi.nlm.nih.gov/pubmed/33847612 http://dx.doi.org/10.1097/MD.0000000000025022 |
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