Cargando…

Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism

To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism. Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patien...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Shuangling, He, Ying, Jin, Fenghua, Liu, Yanjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052084/
https://www.ncbi.nlm.nih.gov/pubmed/33847643
http://dx.doi.org/10.1097/MD.0000000000025432
_version_ 1783679858641993728
author He, Shuangling
He, Ying
Jin, Fenghua
Liu, Yanjie
author_facet He, Shuangling
He, Ying
Jin, Fenghua
Liu, Yanjie
author_sort He, Shuangling
collection PubMed
description To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism. Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patients with type 2 diabetes combined with hypothyroidism who were admitted to the hospital at the same period were selected as the combined group, and 56 patients who came to our hospital for physical examination at the same period were selected as the healthy group. The general clinical data and relevant laboratory indexes of all patients in the three groups were collected and statistically analyzed. Besides, the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated with hypothyroidism was analyzed. Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, TgAb, and HOMA-IR in the diabetes group and combined group were all significantly higher than those in the healthy group, while HDL and T4 levels in the diabetes group and combined group were lower than those in the healthy group (P < .05). The levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, and TgAb in the combined group were significantly higher than those in the diabetes group (P < .05), and the levels of HDL and T4 were lower than those in the diabetes group. In addition, the IGF-1 level was positively correlated with ZAG, nesfatin-1, and HbA1c levels in the combined group (P < .05), and IGF-1 (OR: 0.964, 95% CI: 0.943–0.983, P = .001), ZAG (OR: 1.298, 95% CI: 1.121–1.401, P = .005), nesfatin-1 (OR: 0.876, 95% CI: 0.751–0.901, P = .002), and HbA1c (OR: 1.321, 95% CI: 1.121–1.401, P = .012) were independent risk factors for T2DM complicated with hypothyroidism. Regular detection of IGF-1, ZAG, nesfatin-1, and HbA1c levels are of great value for the diagnosis and treatment of patients with T2DM complicated with hypothyroidism.
format Online
Article
Text
id pubmed-8052084
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-80520842021-04-19 Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism He, Shuangling He, Ying Jin, Fenghua Liu, Yanjie Medicine (Baltimore) 4300 To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes mellitus (T2DM) complicated with hypothyroidism. Fifty-five patients with type-2 diabetes who were admitted to our hospital from August 2018 to February 2020 were selected as the control group, and 55 patients with type 2 diabetes combined with hypothyroidism who were admitted to the hospital at the same period were selected as the combined group, and 56 patients who came to our hospital for physical examination at the same period were selected as the healthy group. The general clinical data and relevant laboratory indexes of all patients in the three groups were collected and statistically analyzed. Besides, the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated with hypothyroidism was analyzed. Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, TgAb, and HOMA-IR in the diabetes group and combined group were all significantly higher than those in the healthy group, while HDL and T4 levels in the diabetes group and combined group were lower than those in the healthy group (P < .05). The levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, and TgAb in the combined group were significantly higher than those in the diabetes group (P < .05), and the levels of HDL and T4 were lower than those in the diabetes group. In addition, the IGF-1 level was positively correlated with ZAG, nesfatin-1, and HbA1c levels in the combined group (P < .05), and IGF-1 (OR: 0.964, 95% CI: 0.943–0.983, P = .001), ZAG (OR: 1.298, 95% CI: 1.121–1.401, P = .005), nesfatin-1 (OR: 0.876, 95% CI: 0.751–0.901, P = .002), and HbA1c (OR: 1.321, 95% CI: 1.121–1.401, P = .012) were independent risk factors for T2DM complicated with hypothyroidism. Regular detection of IGF-1, ZAG, nesfatin-1, and HbA1c levels are of great value for the diagnosis and treatment of patients with T2DM complicated with hypothyroidism. Lippincott Williams & Wilkins 2021-04-16 /pmc/articles/PMC8052084/ /pubmed/33847643 http://dx.doi.org/10.1097/MD.0000000000025432 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle 4300
He, Shuangling
He, Ying
Jin, Fenghua
Liu, Yanjie
Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
title Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
title_full Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
title_fullStr Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
title_full_unstemmed Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
title_short Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
title_sort correlation analysis of igf-1, zag, nesfatin-1, hba(1c) levels, and type 2 diabetes mellitus complicated with hypothyroidism
topic 4300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052084/
https://www.ncbi.nlm.nih.gov/pubmed/33847643
http://dx.doi.org/10.1097/MD.0000000000025432
work_keys_str_mv AT heshuangling correlationanalysisofigf1zagnesfatin1hba1clevelsandtype2diabetesmellituscomplicatedwithhypothyroidism
AT heying correlationanalysisofigf1zagnesfatin1hba1clevelsandtype2diabetesmellituscomplicatedwithhypothyroidism
AT jinfenghua correlationanalysisofigf1zagnesfatin1hba1clevelsandtype2diabetesmellituscomplicatedwithhypothyroidism
AT liuyanjie correlationanalysisofigf1zagnesfatin1hba1clevelsandtype2diabetesmellituscomplicatedwithhypothyroidism