Cargando…

Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer

The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pair GC-rich tract and the structure of the RT-aptamer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tuske, Steve, Zheng, Jie, Olson, Erik D., Ruiz, Francesc X., Pascal, Bruce D., Hoang, Anthony, Bauman, Joseph D., Das, Kalyan, DeStefano, Jeffrey J., Musier-Forsyth, Karin, Griffin, Patrick R., Arnold, Eddy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052095/ https://www.ncbi.nlm.nih.gov/pubmed/33870216 http://dx.doi.org/10.1016/j.crstbi.2020.06.002

Ejemplares similares

Crystal Structure of a Retroviral Polyprotein: Prototype Foamy Virus Protease-Reverse Transcriptase (PR-RT)
por: Harrison, Jerry Joe E. K., et al.
Publicado: (2021)

Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
por: Nguyen, Phuong D M, et al.
Publicado: (2020)

HIV-1 reverse transcriptase complex with DNA and nevirapine reveals nonnucleoside inhibition mechanism
por: Das, Kalyan, et al.
Publicado: (2012)

Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity
por: Alves Ferreira-Bravo, Irani, et al.
Publicado: (2015)

Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase
por: Kuroda, Daniel G., et al.
Publicado: (2013)

Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design
por: Bauman, Joseph D., et al.
Publicado: (2008)

Selection of primer-template sequences that bind human immunodeficiency virus reverse transcriptase with high affinity
por: DeStefano, Jeffrey J., et al.
Publicado: (2006)

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance
por: Das, Kalyan, et al.
Publicado: (2009)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2008)

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase
por: Li, Na, et al.
Publicado: (2009)

A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants
por: Johnson, Barry C, et al.
Publicado: (2012)

Viral Reverse Transcriptases Show Selective High Affinity Binding to DNA-DNA Primer-Templates that Resemble the Polypurine Tract
por: Nair, Gauri R., et al.
Publicado: (2012)

Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach
por: Mansouri, Mahta, et al.
Publicado: (2023)

Conservation of tRNA mimicry in the 5′-untranslated region of distinct HIV-1 subtypes
por: Comandur, Roopa, et al.
Publicado: (2017)

Drug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
por: Singh, Kamalendra, et al.
Publicado: (2014)

Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, “UCAA-motif” RNA Aptamers
por: Whatley, Angela S, et al.
Publicado: (2013)

Progress and outlook in structural biology of large viral RNAs
por: Cantara, William A., et al.
Publicado: (2014)

New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging
por: Olson, Erik D., et al.
Publicado: (2015)

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates
por: Ditzler, Mark A., et al.
Publicado: (2011)

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV
por: Himmel, Daniel M., et al.
Publicado: (2020)

RNA–protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers
por: Lange, Margaret J., et al.
Publicado: (2017)

Insights into HIV-1 Reverse Transcriptase (RT) Inhibition and Drug Resistance from Thirty Years of Structural Studies
por: Singh, Abhimanyu K., et al.
Publicado: (2022)

Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases
por: Michalowski, Daniel, et al.
Publicado: (2008)

Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation
por: Das, Kalyan, et al.
Publicado: (2019)

2′-fluoro-modified pyrimidines enhance affinity of RNA oligonucleotides to HIV-1 reverse transcriptase
por: Gruenke, Paige R., et al.
Publicado: (2020)

Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
por: Dai, Lixin, et al.
Publicado: (2011)

Phosphomimetic S207D Lysyl–tRNA Synthetase Binds HIV-1 5′UTR in an Open Conformation and Increases RNA Dynamics
por: Cantara, William A., et al.
Publicado: (2022)

Active site binding and sequence requirements for inhibition of HIV-1 reverse transcriptase by the RT1 family of single-stranded DNA aptamers
por: Kissel, Jay D., et al.
Publicado: (2007)

Half a century of the reverse transcriptase—happy birthday!
por: Moelling, Karin
Publicado: (2021)

Improvement of Aptamer Affinity by Dimerization
por: Hasegawa, Hijiri, et al.
Publicado: (2008)

Duplex structural differences and not 2′-hydroxyls explain the more stable binding of HIV-reverse transcriptase to RNA-DNA versus DNA-DNA
por: Olimpo, Jeffrey T., et al.
Publicado: (2010)

Alternative divalent cations (Zn(2+), Co(2+), and Mn(2+)) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity
por: Achuthan, Vasudevan, et al.
Publicado: (2015)

A reverse transcriptase ribozyme
por: Samanta, Biswajit, et al.
Publicado: (2017)

Reverse transcriptase activity in psoriatic lesions: effects of reverse transcriptase inhibitors on keratinocyte proliferation and differentiation
por: Molès, Jean-Pierre, et al.
Publicado: (2009)

Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors
por: Jiang, Xiangyi, et al.
Publicado: (2023)

Inhibition of HIV-1 Gag–membrane interactions by specific RNAs
por: Todd, Gabrielle C., et al.
Publicado: (2017)

Transfer RNAs: A treasure trove that keeps on giving
por: Gopalan, Venkat, et al.
Publicado: (2023)

Methods for Improving Aptamer Binding Affinity
por: Hasegawa, Hijiri, et al.
Publicado: (2016)

HIV Reverse Transcriptase Pre-Steady-State Kinetic Analysis of Chain Terminators and Translocation Inhibitors Reveals Interactions between Magnesium and Nucleotide 3′-OH
por: Dilmore, Christopher R., et al.
Publicado: (2021)

Low rates of nucleoside reverse transcriptase inhibitor and nonnucleoside reverse transcriptase inhibitor drug resistance in Botswana
por: Moyo, Sikhulile, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5mjt372frp40ngl0f5t2sq6395