PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis

The DREAM complex orchestrates cell quiescence and the cell cycle. However, how the DREAM complex is deregulated in cancer remains elusive. Here, we report that PAF (PCLAF/KIAA0101) drives cell quiescence exit to promote lung tumorigenesis by remodeling the DREAM complex. PAF is highly expressed in...

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Detalles Bibliográficos
Autores principales: Kim, Moon Jong, Cervantes, Christopher, Jung, Youn-Sang, Zhang, Xiaoshan, Zhang, Jie, Lee, Sung Ho, Jun, Sohee, Litovchick, Larisa, Wang, Wenqi, Chen, Junjie, Fang, Bingliang, Park, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052288/
https://www.ncbi.nlm.nih.gov/pubmed/33626321
http://dx.doi.org/10.1016/j.molcel.2021.02.001

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