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A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK

A reasonable prediction of infectious diseases’ transmission process under different disease control strategies is an important reference point for policy makers. Here we established a dynamic transmission model via Python and realized comprehensive regulation of disease control measures. We classif...

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Autores principales: Zhang, Yuxuan, Gong, Chen, Li, Dawei, Wang, Zhi-Wei, Pu, Shengda D., Robertson, Alex W., Yu, Hong, Parrington, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052322/
https://www.ncbi.nlm.nih.gov/pubmed/33863958
http://dx.doi.org/10.1038/s41598-021-87882-9
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author Zhang, Yuxuan
Gong, Chen
Li, Dawei
Wang, Zhi-Wei
Pu, Shengda D.
Robertson, Alex W.
Yu, Hong
Parrington, John
author_facet Zhang, Yuxuan
Gong, Chen
Li, Dawei
Wang, Zhi-Wei
Pu, Shengda D.
Robertson, Alex W.
Yu, Hong
Parrington, John
author_sort Zhang, Yuxuan
collection PubMed
description A reasonable prediction of infectious diseases’ transmission process under different disease control strategies is an important reference point for policy makers. Here we established a dynamic transmission model via Python and realized comprehensive regulation of disease control measures. We classified government interventions into three categories and introduced three parameters as descriptions for the key points in disease control, these being intraregional growth rate, interregional communication rate, and detection rate of infectors. Our simulation predicts the infection by COVID-19 in the UK would be out of control in 73 days without any interventions; at the same time, herd immunity acquisition will begin from the epicentre. After we introduced government interventions, a single intervention is effective in disease control but at huge expense, while combined interventions would be more efficient, among which, enhancing detection number is crucial in the control strategy for COVID-19. In addition, we calculated requirements for the most effective vaccination strategy based on infection numbers in a real situation. Our model was programmed with iterative algorithms, and visualized via cellular automata; it can be applied to similar epidemics in other regions if the basic parameters are inputted, and is able to synthetically mimic the effect of multiple factors in infectious disease control.
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spelling pubmed-80523222021-04-22 A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK Zhang, Yuxuan Gong, Chen Li, Dawei Wang, Zhi-Wei Pu, Shengda D. Robertson, Alex W. Yu, Hong Parrington, John Sci Rep Article A reasonable prediction of infectious diseases’ transmission process under different disease control strategies is an important reference point for policy makers. Here we established a dynamic transmission model via Python and realized comprehensive regulation of disease control measures. We classified government interventions into three categories and introduced three parameters as descriptions for the key points in disease control, these being intraregional growth rate, interregional communication rate, and detection rate of infectors. Our simulation predicts the infection by COVID-19 in the UK would be out of control in 73 days without any interventions; at the same time, herd immunity acquisition will begin from the epicentre. After we introduced government interventions, a single intervention is effective in disease control but at huge expense, while combined interventions would be more efficient, among which, enhancing detection number is crucial in the control strategy for COVID-19. In addition, we calculated requirements for the most effective vaccination strategy based on infection numbers in a real situation. Our model was programmed with iterative algorithms, and visualized via cellular automata; it can be applied to similar epidemics in other regions if the basic parameters are inputted, and is able to synthetically mimic the effect of multiple factors in infectious disease control. Nature Publishing Group UK 2021-04-16 /pmc/articles/PMC8052322/ /pubmed/33863958 http://dx.doi.org/10.1038/s41598-021-87882-9 Text en © Crown 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zhang, Yuxuan
Gong, Chen
Li, Dawei
Wang, Zhi-Wei
Pu, Shengda D.
Robertson, Alex W.
Yu, Hong
Parrington, John
A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK
title A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK
title_full A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK
title_fullStr A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK
title_full_unstemmed A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK
title_short A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK
title_sort prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of covid-19 in the uk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052322/
https://www.ncbi.nlm.nih.gov/pubmed/33863958
http://dx.doi.org/10.1038/s41598-021-87882-9
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