Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution

The article is devoted to the study of the pharmacokinetics of fullerene C(60) in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C(60) was found in the liver and adrenal glands....

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Autores principales: Semenov, Konstantin N., Ivanova, Daria A., Ageev, Sergei V., Petrov, Andrey V., Podolsky, Nikita E., Volochaeva, Ekaterina M., Fedorova, Ekaterina M., Meshcheriakov, Anatolii A., Zakharov, Egor E., Murin, Igor V., Sharoyko, Vladimir V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052328/
https://www.ncbi.nlm.nih.gov/pubmed/33863918
http://dx.doi.org/10.1038/s41598-021-87014-3
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author Semenov, Konstantin N.
Ivanova, Daria A.
Ageev, Sergei V.
Petrov, Andrey V.
Podolsky, Nikita E.
Volochaeva, Ekaterina M.
Fedorova, Ekaterina M.
Meshcheriakov, Anatolii A.
Zakharov, Egor E.
Murin, Igor V.
Sharoyko, Vladimir V.
author_facet Semenov, Konstantin N.
Ivanova, Daria A.
Ageev, Sergei V.
Petrov, Andrey V.
Podolsky, Nikita E.
Volochaeva, Ekaterina M.
Fedorova, Ekaterina M.
Meshcheriakov, Anatolii A.
Zakharov, Egor E.
Murin, Igor V.
Sharoyko, Vladimir V.
author_sort Semenov, Konstantin N.
collection PubMed
description The article is devoted to the study of the pharmacokinetics of fullerene C(60) in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C(60) was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C(60) in the micellar form is higher than that in an oil solution.
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spelling pubmed-80523282021-04-22 Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution Semenov, Konstantin N. Ivanova, Daria A. Ageev, Sergei V. Petrov, Andrey V. Podolsky, Nikita E. Volochaeva, Ekaterina M. Fedorova, Ekaterina M. Meshcheriakov, Anatolii A. Zakharov, Egor E. Murin, Igor V. Sharoyko, Vladimir V. Sci Rep Article The article is devoted to the study of the pharmacokinetics of fullerene C(60) in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C(60) was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C(60) in the micellar form is higher than that in an oil solution. Nature Publishing Group UK 2021-04-16 /pmc/articles/PMC8052328/ /pubmed/33863918 http://dx.doi.org/10.1038/s41598-021-87014-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Semenov, Konstantin N.
Ivanova, Daria A.
Ageev, Sergei V.
Petrov, Andrey V.
Podolsky, Nikita E.
Volochaeva, Ekaterina M.
Fedorova, Ekaterina M.
Meshcheriakov, Anatolii A.
Zakharov, Egor E.
Murin, Igor V.
Sharoyko, Vladimir V.
Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution
title Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution
title_full Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution
title_fullStr Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution
title_full_unstemmed Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution
title_short Evaluation of the C(60) biodistribution in mice in a micellar ExtraOx form and in an oil solution
title_sort evaluation of the c(60) biodistribution in mice in a micellar extraox form and in an oil solution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052328/
https://www.ncbi.nlm.nih.gov/pubmed/33863918
http://dx.doi.org/10.1038/s41598-021-87014-3
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