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Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery
This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and 2018. Wo...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052330/ https://www.ncbi.nlm.nih.gov/pubmed/33863969 http://dx.doi.org/10.1038/s41598-021-87846-z |
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author | Rubin, Hadas Rom, Eyal Wattad, Malak Seh, Khadeje Levy, Natanel Jehassi, Ayellet Romano, Shabtai Salim, Raed |
author_facet | Rubin, Hadas Rom, Eyal Wattad, Malak Seh, Khadeje Levy, Natanel Jehassi, Ayellet Romano, Shabtai Salim, Raed |
author_sort | Rubin, Hadas |
collection | PubMed |
description | This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and 2018. Women who delivered by CD were divided into two groups according to AP timing before skin incision: group 1 within 30 min, and group 2 from 30 to 60 min. The primary outcome was the incidence of any infectious morbidity. Overall, 2989 women were eligible: 2791 in group 1 and 198 in group 2. The primary composite outcome occurred in 125 women (4.48%) in group 1 and 8 women (4.04%) in group 2 (OR, 1.11; 95% CI 0.54–2.31; P = 0.77). The rate of surgical site infection only, was 1.08% in group 1 and 0.51% in group 2 (OR, 2.13; 95% CI 0.29–15.70; P = 0.72). The incidence was comparable between the groups in a separate sub-analysis restricted to laboring CDs and obese women. The rate of infectious morbidity was similar among women who received AP within 30 min and from 30 to 60 min before skin incision. |
format | Online Article Text |
id | pubmed-8052330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80523302021-04-22 Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery Rubin, Hadas Rom, Eyal Wattad, Malak Seh, Khadeje Levy, Natanel Jehassi, Ayellet Romano, Shabtai Salim, Raed Sci Rep Article This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and 2018. Women who delivered by CD were divided into two groups according to AP timing before skin incision: group 1 within 30 min, and group 2 from 30 to 60 min. The primary outcome was the incidence of any infectious morbidity. Overall, 2989 women were eligible: 2791 in group 1 and 198 in group 2. The primary composite outcome occurred in 125 women (4.48%) in group 1 and 8 women (4.04%) in group 2 (OR, 1.11; 95% CI 0.54–2.31; P = 0.77). The rate of surgical site infection only, was 1.08% in group 1 and 0.51% in group 2 (OR, 2.13; 95% CI 0.29–15.70; P = 0.72). The incidence was comparable between the groups in a separate sub-analysis restricted to laboring CDs and obese women. The rate of infectious morbidity was similar among women who received AP within 30 min and from 30 to 60 min before skin incision. Nature Publishing Group UK 2021-04-16 /pmc/articles/PMC8052330/ /pubmed/33863969 http://dx.doi.org/10.1038/s41598-021-87846-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Rubin, Hadas Rom, Eyal Wattad, Malak Seh, Khadeje Levy, Natanel Jehassi, Ayellet Romano, Shabtai Salim, Raed Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
title | Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
title_full | Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
title_fullStr | Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
title_full_unstemmed | Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
title_short | Effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
title_sort | effectiveness of antimicrobial prophylaxis at 30 versus 60 min before cesarean delivery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052330/ https://www.ncbi.nlm.nih.gov/pubmed/33863969 http://dx.doi.org/10.1038/s41598-021-87846-z |
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