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Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish

Leucyl-tRNA synthetase (LARS) is an enzyme that catalyses the ligation of leucine with leucine tRNA. LARS is also essential to sensitize the intracellular leucine concentration to the mammalian target of rapamycin complex 1 (mTORC1) activation. Biallelic mutation in the LARS gene causes infantile li...

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Detalles Bibliográficos
Autores principales:	Inoue, Masanori, Miyahara, Hiroaki, Shiraishi, Hiroshi, Shimizu, Nobuyuki, Tsumori, Mika, Kiyota, Kyoko, Maeda, Miwako, Umeda, Ryohei, Ishitani, Tohru, Hanada, Reiko, Ihara, Kenji, Hanada, Toshikatsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052342/ https://www.ncbi.nlm.nih.gov/pubmed/33863987 http://dx.doi.org/10.1038/s41598-021-87879-4

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