DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death

Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast cancer. Cancer cells expressing higher DUSP16 are in...

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Detalles Bibliográficos
Autores principales: Low, Heng Boon, Wong, Zhen Lim, Wu, Bangyuan, Kong, Li Ren, Png, Chin Wen, Cho, Yik-Lam, Li, Chun-Wei, Xiao, Fengchun, Xin, Xuan, Yang, Henry, Loo, Jia Min, Lee, Fiona Yi Xin, Tan, Iain Bee Huat, DasGupta, Ramanuj, Shen, Han-Ming, Schwarz, Herbert, Gascoigne, Nicholas R. J., Goh, Boon Cher, Xu, Xiaohong, Zhang, Yongliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052345/
https://www.ncbi.nlm.nih.gov/pubmed/33863904
http://dx.doi.org/10.1038/s41467-021-22638-7

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