Cargando…

TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation

Mycobacterial cell-wall glycolipids elicit an anti-mycobacterial immune response via FcRγ-associated C-type lectin receptors, including Mincle, and caspase-recruitment domain family member 9 (CARD9). Additionally, mycobacteria harbor immuno-evasive cell-wall lipids associated with virulence and late...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iizasa, Ei’ichi, Chuma, Yasushi, Uematsu, Takayuki, Kubota, Mio, Kawaguchi, Hiroaki, Umemura, Masayuki, Toyonaga, Kenji, Kiyohara, Hideyasu, Yano, Ikuya, Colonna, Marco, Sugita, Masahiko, Matsuzaki, Goro, Yamasaki, Sho, Yoshida, Hiroki, Hara, Hiromitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052348/ https://www.ncbi.nlm.nih.gov/pubmed/33863908 http://dx.doi.org/10.1038/s41467-021-22620-3

Ejemplares similares

Adjuvant activity of Mycobacteria-derived mycolic acids
por: Kubota, Mio, et al.
Publicado: (2020)

Cationized liposomal keto-mycolic acids isolated from Mycobacterium bovis bacillus Calmette-Guérin induce antitumor immunity in a syngeneic murine bladder cancer model
por: Yoshino, Takayuki, et al.
Publicado: (2019)

Loss of CARD9-mediated innate activation attenuates severe influenza pneumonia without compromising host viral immunity
por: Uematsu, Takayuki, et al.
Publicado: (2015)

Ion mobility mass spectrometry for the study of mycobacterial mycolic acids
por: Liu, Yi, et al.
Publicado: (2023)

MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
por: Varela, Cristian, et al.
Publicado: (2012)

The mycobacterial desaturase DesA2 is associated with mycolic acid biosynthesis
por: Bailo, Rebeca, et al.
Publicado: (2022)

Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in Mycobacteria
por: Alahari, Anuradha, et al.
Publicado: (2007)

Role of long-chain acyl-CoAs in the regulation of mycolic acid biosynthesis in mycobacteria
por: Tsai, Yi Ting, et al.
Publicado: (2017)

Path‐seq identifies an essential mycolate remodeling program for mycobacterial host adaptation
por: Peterson, Eliza JR, et al.
Publicado: (2019)

Crystal structure of FadD32, an enzyme essential for mycolic acid biosynthesis in mycobacteria
por: Li, Wenjuan, et al.
Publicado: (2015)

Two Accessory Proteins Govern MmpL3 Mycolic Acid Transport in Mycobacteria
por: Fay, Allison, et al.
Publicado: (2019)

The driving force for mycolic acid export by mycobacterial MmpL3 is proton translocation
por: Parish, Tanya
Publicado: (2022)

MadR mediates acyl CoA-dependent regulation of mycolic acid desaturation in mycobacteria
por: Cooper, Charlotte, et al.
Publicado: (2022)

Unveiling the Biosynthetic Pathway for Short Mycolic Acids in Nontuberculous Mycobacteria: Mycobacterium smegmatis MSMEG_4301 and Its Ortholog Mycobacterium abscessus MAB_1915 Are Essential for the Synthesis of α′-Mycolic Acids
por: Di Capua, Cecilia B., et al.
Publicado: (2022)

Characterization of the Receptors for Mycobacterial Cord Factor in Guinea Pig
por: Toyonaga, Kenji, et al.
Publicado: (2014)

The mycolic acid reductase Rv2509 has distinct structural motifs and is essential for growth in slow‐growing mycobacteria
por: Javid, Asma, et al.
Publicado: (2019)

Arabidopsis LBP/BPI related-1 and -2 bind to LPS directly and regulate PR1 expression
por: Iizasa, Sayaka, et al.
Publicado: (2016)

Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice
por: Ishikawa, Asako, et al.
Publicado: (2019)

The biology of TREM receptors
por: Colonna, Marco
Publicado: (2023)

Synthesis of a Di-Mycoloyl Tri-Arabinofuranosyl Glycerol Fragment of the Mycobacterial Cell Wall, Based on Synthetic Mycolic Acids
por: Ali, Omar T., et al.
Publicado: (2019)

PatA Regulates Isoniazid Resistance by Mediating Mycolic Acid Synthesis and Controls Biofilm Formation by Affecting Lipid Synthesis in Mycobacteria
por: Wang, Kun, et al.
Publicado: (2023)

Transcriptome analysis reveals key roles of AtLBR-2 in LPS-induced defense responses in plants
por: Iizasa, Sayaka, et al.
Publicado: (2017)

Time to Expand the Picture of Mycobacterial Lipids: Spotlight on Nontuberculous Mycobacteria
por: Kurz, Sebastian G., et al.
Publicado: (2020)

Identification of Novel Mycobacterial Inhibitors Against Mycobacterial Protein Kinase G
por: Kanehiro, Yuichi, et al.
Publicado: (2018)

HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness
por: Lefebvre, Cyril, et al.
Publicado: (2018)

Interleukin-27 controls basal pain threshold in physiological and pathological conditions
por: Sasaguri, Tomoko, et al.
Publicado: (2018)

Loss of a Mycobacterial Gene Encoding a Reductase Leads to an Altered Cell Wall Containing β-oxo- Mycolic Acid Analogs and Accumulation of Ketones
por: Bhatt, Apoorva, et al.
Publicado: (2008)

In vivo imaging of MmpL transporters reveals distinct subcellular locations for export of mycolic acids and non-essential trehalose polyphleates in the mycobacterial outer membrane
por: Thouvenel, Laurie, et al.
Publicado: (2023)

L-CBM signaling in lymphocyte development and function
por: Hara, Hiromitsu, et al.
Publicado: (2010)

The Impact of Nontuberculous Mycobacteria Species on Mortality in Patients With Nontuberculous Mycobacterial Lung Disease
por: Wang, Ping-Huai, et al.
Publicado: (2022)

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease
por: Zhou, Yingyue, et al.
Publicado: (2018)

Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
por: Ishikawa, Eri, et al.
Publicado: (2009)

Structure–function relationships of the antigenicity of mycolic acids in tuberculosis patients
por: Beukes, Mervyn, et al.
Publicado: (2010)

Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillus
por: Nataraj, Vijayashankar, et al.
Publicado: (2015)

Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis
por: Tahiri, Nabil, et al.
Publicado: (2020)

Intimate relationships among actinomycetes and mycolic acid-containing bacteria
por: Kato, Manami, et al.
Publicado: (2022)

Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals
por: Cella, Marina, et al.
Publicado: (2003)

TREM2 dependent and independent functions of microglia in Alzheimer’s disease
por: Hou, Jinchao, et al.
Publicado: (2022)

Septum site placement in Mycobacteria – identification and characterisation of mycobacterial homologues of Escherichia coli MinD
por: Kishore, Vimal, et al.
Publicado: (2023)

INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE
por: Grzegorzewicz, Anna E., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a5u8113j1941toaqs6mi7q8q5d