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Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1

Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V1), in co...

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Autores principales: Herrero, Jose L., Thiele, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052350/
https://www.ncbi.nlm.nih.gov/pubmed/33863988
http://dx.doi.org/10.1038/s41598-021-88044-7
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author Herrero, Jose L.
Thiele, Alexander
author_facet Herrero, Jose L.
Thiele, Alexander
author_sort Herrero, Jose L.
collection PubMed
description Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V1), in conjunction with feedback from higher visual areas. The strength of lateral interactions is affected by cholinergic neuromodulation. Blockade of muscarinic receptors should increase the strength of lateral intracortical interactions, while nicotinic blockade should reduce thalamocortical feed-forward drive. Here we test this proposal through local iontophoretic application of the muscarinic receptor antagonist scopolamine and the nicotinic receptor antagonist mecamylamine, while recording single cells in parafoveal representations in awake fixating macaque V1. Collinear flankers generally reduced neuronal contrast sensitivity. Muscarinic and nicotinic receptor blockade equally reduced neuronal contrast sensitivity. Contrary to our hypothesis, flanker interactions were not systematically affected by either receptor blockade.
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spelling pubmed-80523502021-04-22 Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1 Herrero, Jose L. Thiele, Alexander Sci Rep Article Context affects the salience and visibility of image elements in visual scenes. Collinear flankers can enhance or decrease the perceptual and neuronal sensitivity to flanked stimuli. These effects are mediated through lateral interactions between neurons in the primary visual cortex (area V1), in conjunction with feedback from higher visual areas. The strength of lateral interactions is affected by cholinergic neuromodulation. Blockade of muscarinic receptors should increase the strength of lateral intracortical interactions, while nicotinic blockade should reduce thalamocortical feed-forward drive. Here we test this proposal through local iontophoretic application of the muscarinic receptor antagonist scopolamine and the nicotinic receptor antagonist mecamylamine, while recording single cells in parafoveal representations in awake fixating macaque V1. Collinear flankers generally reduced neuronal contrast sensitivity. Muscarinic and nicotinic receptor blockade equally reduced neuronal contrast sensitivity. Contrary to our hypothesis, flanker interactions were not systematically affected by either receptor blockade. Nature Publishing Group UK 2021-04-16 /pmc/articles/PMC8052350/ /pubmed/33863988 http://dx.doi.org/10.1038/s41598-021-88044-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Herrero, Jose L.
Thiele, Alexander
Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_full Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_fullStr Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_full_unstemmed Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_short Effects of muscarinic and nicotinic receptors on contextual modulation in macaque area V1
title_sort effects of muscarinic and nicotinic receptors on contextual modulation in macaque area v1
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052350/
https://www.ncbi.nlm.nih.gov/pubmed/33863988
http://dx.doi.org/10.1038/s41598-021-88044-7
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