Deletion of Mfsd2b impairs thrombotic functions of platelets

We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report that Mfsd2b is critical for the release of all S1P species in both resting and activated platelets. We show that resting platelets store S1P in the cytoplasm. After activation, this S1P pool is delive...

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Detalles Bibliográficos
Autores principales: Chandrakanthan, Madhuvanthi, Nguyen, Toan Quoc, Hasan, Zafrul, Muralidharan, Sneha, Vu, Thiet Minh, Li, Aaron Wei Liang, Le, Uyen Thanh Nha, Thi Thuy Ha, Hoa, Baik, Sang-Ha, Tan, Sock Hwee, Foo, Juat Chin, Wenk, Markus R., Cazenave-Gassiot, Amaury, Torta, Federico, Ong, Wei Yi, Chan, Mark Yan Yee, Nguyen, Long N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052357/
https://www.ncbi.nlm.nih.gov/pubmed/33863882
http://dx.doi.org/10.1038/s41467-021-22642-x

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