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Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

Both adenine base editors (ABEs) and cytosine base editors (CBEs) have been recently revealed to induce transcriptome-wide RNA off-target editing in a guide RNA-independent manner. Here we construct a reporter system containing E.coli Hokb gene with a tRNA-like motif for robust detection of RNA edit...

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Detalles Bibliográficos
Autores principales:	Li, Jianan, Yu, Wenxia, Huang, Shisheng, Wu, Susu, Li, Liping, Zhou, Jiankui, Cao, Yu, Huang, Xingxu, Qiao, Yunbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052359/ https://www.ncbi.nlm.nih.gov/pubmed/33863894 http://dx.doi.org/10.1038/s41467-021-22519-z

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