Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by interacting with and antagonizing the anti-apoptotic proteins BCL-xL and BCL-2. However, the mechanisms by which p53 induces mitochondrial apopt...

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Detalles Bibliográficos
Autores principales: Wei, Hudie, Qu, Lingzhi, Dai, Shuyan, Li, Yun, Wang, Haolan, Feng, Yilu, Chen, Xiaojuan, Jiang, Longying, Guo, Ming, Li, Jun, Chen, Zhuchu, Chen, Lin, Zhang, Ye, Chen, Yongheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052441/
https://www.ncbi.nlm.nih.gov/pubmed/33863900
http://dx.doi.org/10.1038/s41467-021-22655-6

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