Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A...

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Detalles Bibliográficos
Autores principales: Recasens, Ariadna, Humphrey, Sean J., Ellis, Michael, Hoque, Monira, Abbassi, Ramzi H., Chen, Brianna, Longworth, Mitchell, Needham, Elise J., James, David E., Johns, Terrance G., Day, Bryan W., Kassiou, Michael, Yang, Pengyi, Munoz, Lenka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052442/
https://www.ncbi.nlm.nih.gov/pubmed/33863878
http://dx.doi.org/10.1038/s41420-021-00456-6

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