Functional responsiveness of memory T cells from COVID-19 patients

The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed...

Descripción completa

Detalles Bibliográficos
Autores principales: Tavukcuoglu, Ece, Horzum, Utku, Cagkan Inkaya, Ahmet, Unal, Serhat, Esendagli, Gunes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052500/
https://www.ncbi.nlm.nih.gov/pubmed/33905951
http://dx.doi.org/10.1016/j.cellimm.2021.104363
Descripción
Sumario:The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4(+) and CD8(+) effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.

Ejemplares similares