Functional responsiveness of memory T cells from COVID-19 patients

The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed...

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Autores principales: Tavukcuoglu, Ece, Horzum, Utku, Cagkan Inkaya, Ahmet, Unal, Serhat, Esendagli, Gunes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052500/
https://www.ncbi.nlm.nih.gov/pubmed/33905951
http://dx.doi.org/10.1016/j.cellimm.2021.104363
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author Tavukcuoglu, Ece
Horzum, Utku
Cagkan Inkaya, Ahmet
Unal, Serhat
Esendagli, Gunes
author_facet Tavukcuoglu, Ece
Horzum, Utku
Cagkan Inkaya, Ahmet
Unal, Serhat
Esendagli, Gunes
author_sort Tavukcuoglu, Ece
collection PubMed
description The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4(+) and CD8(+) effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2.
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spelling pubmed-80525002021-04-19 Functional responsiveness of memory T cells from COVID-19 patients Tavukcuoglu, Ece Horzum, Utku Cagkan Inkaya, Ahmet Unal, Serhat Esendagli, Gunes Cell Immunol Short Communication The presence of memory T cells in COVID-19 patients has been acknowledged, however the functional potency of memory responses is critical for protection. In this study, naïve, effector, effector memory, and central memory CD4(+) and CD8(+) T cells obtained from the COVID-19 survivors were re-exposed to autologous monocyte-derived DCs that were loaded with SARS-CoV-2 spike glycoprotein S1. Proliferation capacity, CD25, 4-1BB, and PD-1 expression, and IFN-γ, IL-6, granzyme, granulysin, and FasL secretion were enhanced in CD4(+) and CD8(+) effector memory and central memory T cells. Albeit being at heterogeneous levels, the memory T cells from the individuals with COVID-19 history possess functional capacities to reinvigorate anti-viral immunity against SARS-CoV-2. Elsevier Inc. 2021-07 2021-04-17 /pmc/articles/PMC8052500/ /pubmed/33905951 http://dx.doi.org/10.1016/j.cellimm.2021.104363 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Tavukcuoglu, Ece
Horzum, Utku
Cagkan Inkaya, Ahmet
Unal, Serhat
Esendagli, Gunes
Functional responsiveness of memory T cells from COVID-19 patients
title Functional responsiveness of memory T cells from COVID-19 patients
title_full Functional responsiveness of memory T cells from COVID-19 patients
title_fullStr Functional responsiveness of memory T cells from COVID-19 patients
title_full_unstemmed Functional responsiveness of memory T cells from COVID-19 patients
title_short Functional responsiveness of memory T cells from COVID-19 patients
title_sort functional responsiveness of memory t cells from covid-19 patients
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052500/
https://www.ncbi.nlm.nih.gov/pubmed/33905951
http://dx.doi.org/10.1016/j.cellimm.2021.104363
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