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Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction

Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which was mainly related to endothelial cell dysfunction. Apelin, an adipokine that is upregulated in diabetes mellitus, was reported to improve endothelial cell dysfunction and attenuate cardiac insufficiency ind...

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Autores principales: Li, Bin, Yin, Jiming, Chang, Jing, Zhang, Jia, Wang, Yangjia, Huang, Haixia, Wang, Wei, Zeng, Xiangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052525/
https://www.ncbi.nlm.nih.gov/pubmed/33504680
http://dx.doi.org/10.1530/JOE-20-0398
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author Li, Bin
Yin, Jiming
Chang, Jing
Zhang, Jia
Wang, Yangjia
Huang, Haixia
Wang, Wei
Zeng, Xiangjun
author_facet Li, Bin
Yin, Jiming
Chang, Jing
Zhang, Jia
Wang, Yangjia
Huang, Haixia
Wang, Wei
Zeng, Xiangjun
author_sort Li, Bin
collection PubMed
description Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which was mainly related to endothelial cell dysfunction. Apelin, an adipokine that is upregulated in diabetes mellitus, was reported to improve endothelial cell dysfunction and attenuate cardiac insufficiency induced by ischemia and reperfusion. Therefore, it is hypothesized that apelin might be involved in alleviating endothelial cell dysfunction and followed cardiomyopathy in diabetes mellitus. The results showed that apelin improved endothelial cell dysfunction via decreasing apoptosis and expression of adhesion molecules and increasing proliferation, angiogenesis, and expression of E-cadherin, VEGFR 2 and Tie-2 in endothelial cells, which resulted in the attenuation of the capillary permeability in cardiac tissues and following diabetic cardiomyopathy. Meanwhile, the results from endothelial cell-specific APJ knockout mice and cultured endothelial cells confirmed that the effects of apelin on endothelial cells were dependent on APJ and the downstream NFκB pathways. In conclusion, apelin might reduce microvascular dysfunction induced by diabetes mellitus via improving endothelial dysfunction dependent on APJ activated NFκB pathways.
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spelling pubmed-80525252021-04-21 Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction Li, Bin Yin, Jiming Chang, Jing Zhang, Jia Wang, Yangjia Huang, Haixia Wang, Wei Zeng, Xiangjun J Endocrinol Research Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which was mainly related to endothelial cell dysfunction. Apelin, an adipokine that is upregulated in diabetes mellitus, was reported to improve endothelial cell dysfunction and attenuate cardiac insufficiency induced by ischemia and reperfusion. Therefore, it is hypothesized that apelin might be involved in alleviating endothelial cell dysfunction and followed cardiomyopathy in diabetes mellitus. The results showed that apelin improved endothelial cell dysfunction via decreasing apoptosis and expression of adhesion molecules and increasing proliferation, angiogenesis, and expression of E-cadherin, VEGFR 2 and Tie-2 in endothelial cells, which resulted in the attenuation of the capillary permeability in cardiac tissues and following diabetic cardiomyopathy. Meanwhile, the results from endothelial cell-specific APJ knockout mice and cultured endothelial cells confirmed that the effects of apelin on endothelial cells were dependent on APJ and the downstream NFκB pathways. In conclusion, apelin might reduce microvascular dysfunction induced by diabetes mellitus via improving endothelial dysfunction dependent on APJ activated NFκB pathways. Bioscientifica Ltd 2021-01-25 /pmc/articles/PMC8052525/ /pubmed/33504680 http://dx.doi.org/10.1530/JOE-20-0398 Text en © 2021 The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Li, Bin
Yin, Jiming
Chang, Jing
Zhang, Jia
Wang, Yangjia
Huang, Haixia
Wang, Wei
Zeng, Xiangjun
Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
title Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
title_full Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
title_fullStr Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
title_full_unstemmed Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
title_short Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
title_sort apelin/apj relieve diabetic cardiomyopathy by reducing microvascular dysfunction
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052525/
https://www.ncbi.nlm.nih.gov/pubmed/33504680
http://dx.doi.org/10.1530/JOE-20-0398
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