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Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction
Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which was mainly related to endothelial cell dysfunction. Apelin, an adipokine that is upregulated in diabetes mellitus, was reported to improve endothelial cell dysfunction and attenuate cardiac insufficiency ind...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052525/ https://www.ncbi.nlm.nih.gov/pubmed/33504680 http://dx.doi.org/10.1530/JOE-20-0398 |
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author | Li, Bin Yin, Jiming Chang, Jing Zhang, Jia Wang, Yangjia Huang, Haixia Wang, Wei Zeng, Xiangjun |
author_facet | Li, Bin Yin, Jiming Chang, Jing Zhang, Jia Wang, Yangjia Huang, Haixia Wang, Wei Zeng, Xiangjun |
author_sort | Li, Bin |
collection | PubMed |
description | Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which was mainly related to endothelial cell dysfunction. Apelin, an adipokine that is upregulated in diabetes mellitus, was reported to improve endothelial cell dysfunction and attenuate cardiac insufficiency induced by ischemia and reperfusion. Therefore, it is hypothesized that apelin might be involved in alleviating endothelial cell dysfunction and followed cardiomyopathy in diabetes mellitus. The results showed that apelin improved endothelial cell dysfunction via decreasing apoptosis and expression of adhesion molecules and increasing proliferation, angiogenesis, and expression of E-cadherin, VEGFR 2 and Tie-2 in endothelial cells, which resulted in the attenuation of the capillary permeability in cardiac tissues and following diabetic cardiomyopathy. Meanwhile, the results from endothelial cell-specific APJ knockout mice and cultured endothelial cells confirmed that the effects of apelin on endothelial cells were dependent on APJ and the downstream NFκB pathways. In conclusion, apelin might reduce microvascular dysfunction induced by diabetes mellitus via improving endothelial dysfunction dependent on APJ activated NFκB pathways. |
format | Online Article Text |
id | pubmed-8052525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-80525252021-04-21 Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction Li, Bin Yin, Jiming Chang, Jing Zhang, Jia Wang, Yangjia Huang, Haixia Wang, Wei Zeng, Xiangjun J Endocrinol Research Microcirculatory injuries had been reported to be involved in diabetic cardiomyopathy, which was mainly related to endothelial cell dysfunction. Apelin, an adipokine that is upregulated in diabetes mellitus, was reported to improve endothelial cell dysfunction and attenuate cardiac insufficiency induced by ischemia and reperfusion. Therefore, it is hypothesized that apelin might be involved in alleviating endothelial cell dysfunction and followed cardiomyopathy in diabetes mellitus. The results showed that apelin improved endothelial cell dysfunction via decreasing apoptosis and expression of adhesion molecules and increasing proliferation, angiogenesis, and expression of E-cadherin, VEGFR 2 and Tie-2 in endothelial cells, which resulted in the attenuation of the capillary permeability in cardiac tissues and following diabetic cardiomyopathy. Meanwhile, the results from endothelial cell-specific APJ knockout mice and cultured endothelial cells confirmed that the effects of apelin on endothelial cells were dependent on APJ and the downstream NFκB pathways. In conclusion, apelin might reduce microvascular dysfunction induced by diabetes mellitus via improving endothelial dysfunction dependent on APJ activated NFκB pathways. Bioscientifica Ltd 2021-01-25 /pmc/articles/PMC8052525/ /pubmed/33504680 http://dx.doi.org/10.1530/JOE-20-0398 Text en © 2021 The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Li, Bin Yin, Jiming Chang, Jing Zhang, Jia Wang, Yangjia Huang, Haixia Wang, Wei Zeng, Xiangjun Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
title | Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
title_full | Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
title_fullStr | Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
title_full_unstemmed | Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
title_short | Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
title_sort | apelin/apj relieve diabetic cardiomyopathy by reducing microvascular dysfunction |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052525/ https://www.ncbi.nlm.nih.gov/pubmed/33504680 http://dx.doi.org/10.1530/JOE-20-0398 |
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