The aging endothelium

Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic d...

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Detalles Bibliográficos
Autores principales: Ting, Ka Ka, Coleman, Paul, Zhao, Yang, Vadas, Mathew A, Gamble, Jennifer R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052565/
https://www.ncbi.nlm.nih.gov/pubmed/33880430
http://dx.doi.org/10.1530/VB-20-0013
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author Ting, Ka Ka
Coleman, Paul
Zhao, Yang
Vadas, Mathew A
Gamble, Jennifer R
author_facet Ting, Ka Ka
Coleman, Paul
Zhao, Yang
Vadas, Mathew A
Gamble, Jennifer R
author_sort Ting, Ka Ka
collection PubMed
description Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases.
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spelling pubmed-80525652021-04-19 The aging endothelium Ting, Ka Ka Coleman, Paul Zhao, Yang Vadas, Mathew A Gamble, Jennifer R Vasc Biol Review Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases. Bioscientifica Ltd 2021-01-12 /pmc/articles/PMC8052565/ /pubmed/33880430 http://dx.doi.org/10.1530/VB-20-0013 Text en © 2021 The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ting, Ka Ka
Coleman, Paul
Zhao, Yang
Vadas, Mathew A
Gamble, Jennifer R
The aging endothelium
title The aging endothelium
title_full The aging endothelium
title_fullStr The aging endothelium
title_full_unstemmed The aging endothelium
title_short The aging endothelium
title_sort aging endothelium
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052565/
https://www.ncbi.nlm.nih.gov/pubmed/33880430
http://dx.doi.org/10.1530/VB-20-0013
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