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The aging endothelium
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052565/ https://www.ncbi.nlm.nih.gov/pubmed/33880430 http://dx.doi.org/10.1530/VB-20-0013 |
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author | Ting, Ka Ka Coleman, Paul Zhao, Yang Vadas, Mathew A Gamble, Jennifer R |
author_facet | Ting, Ka Ka Coleman, Paul Zhao, Yang Vadas, Mathew A Gamble, Jennifer R |
author_sort | Ting, Ka Ka |
collection | PubMed |
description | Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases. |
format | Online Article Text |
id | pubmed-8052565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-80525652021-04-19 The aging endothelium Ting, Ka Ka Coleman, Paul Zhao, Yang Vadas, Mathew A Gamble, Jennifer R Vasc Biol Review Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases. Endothelial senescence can result in systemic metabolic changes, implicating senescence in chronic diseases such as diabetes, obesity and atherosclerosis. Senolytics, drugs that eliminate senescent cells, afford new therapeutic strategies for control of these chronic diseases. Bioscientifica Ltd 2021-01-12 /pmc/articles/PMC8052565/ /pubmed/33880430 http://dx.doi.org/10.1530/VB-20-0013 Text en © 2021 The authors https://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Ting, Ka Ka Coleman, Paul Zhao, Yang Vadas, Mathew A Gamble, Jennifer R The aging endothelium |
title | The aging endothelium |
title_full | The aging endothelium |
title_fullStr | The aging endothelium |
title_full_unstemmed | The aging endothelium |
title_short | The aging endothelium |
title_sort | aging endothelium |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052565/ https://www.ncbi.nlm.nih.gov/pubmed/33880430 http://dx.doi.org/10.1530/VB-20-0013 |
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