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Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size

Intrauterine growth restriction (IUGR) reflects inadequate growth in-utero and is prevalent in low resource settings. This study aimed to assess the association of maternal delivery parathyroid hormone (PTH) – a regulator of bone turnover and calcium homeostasis – with newborn anthropometry, to iden...

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Autores principales: Qamar, Huma, Perumal, Nandita, Papp, Eszter, Gernand, Alison D, Al Mahmud, Abdullah, Roth, Daniel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052570/
https://www.ncbi.nlm.nih.gov/pubmed/33640873
http://dx.doi.org/10.1530/EC-21-0056
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author Qamar, Huma
Perumal, Nandita
Papp, Eszter
Gernand, Alison D
Al Mahmud, Abdullah
Roth, Daniel E
author_facet Qamar, Huma
Perumal, Nandita
Papp, Eszter
Gernand, Alison D
Al Mahmud, Abdullah
Roth, Daniel E
author_sort Qamar, Huma
collection PubMed
description Intrauterine growth restriction (IUGR) reflects inadequate growth in-utero and is prevalent in low resource settings. This study aimed to assess the association of maternal delivery parathyroid hormone (PTH) – a regulator of bone turnover and calcium homeostasis – with newborn anthropometry, to identify regulators of PTH, and to delineate pathways by which maternal PTH regulates birth size using path analysis. This was a cross-sectional analysis of data from participants (n = 537) enrolled in the Maternal Vitamin D for Infant Growth trial in Dhaka, Bangladesh. Primary exposures were maternal delivery intact PTH (iPTH) or whole PTH (wPTH) and outcomes were gestational age- and sex-standardized z-scores for birth length (LAZ), weight (WAZ), and head circumference (HCAZ). Hypothesized regulators of PTH included calcium and protein intake, vitamin D, magnesium, fibroblast-like growth factor-23 (FGF23), and C-reactive protein. Maternal iPTH was not associated with birth size in linear regression analyses; however, in path analysis models, every SD increase in log(iPTH) was associated with 0.08SD (95% CI: 0.002, 0.162) higher LAZ. In linear regression and path analysis models, wPTH was positively associated with WAZ. Vitamin D suppressed PTH, while FGF23 was positively associated with PTH. In path analysis models, higher magnesium was negatively associated with LAZ; FGF23 was positively associated and protein intake was negatively associated with LAZ, WAZ, and HCAZ. Higher maternal PTH in late pregnancy is unlikely to contribute to IUGR. Future studies should investigate maternal FGF23, magnesium and protein intake as regulators of fetal growth, particularly in settings where food insecurity and IUGR are public health problems.
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spelling pubmed-80525702021-04-21 Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size Qamar, Huma Perumal, Nandita Papp, Eszter Gernand, Alison D Al Mahmud, Abdullah Roth, Daniel E Endocr Connect Research Intrauterine growth restriction (IUGR) reflects inadequate growth in-utero and is prevalent in low resource settings. This study aimed to assess the association of maternal delivery parathyroid hormone (PTH) – a regulator of bone turnover and calcium homeostasis – with newborn anthropometry, to identify regulators of PTH, and to delineate pathways by which maternal PTH regulates birth size using path analysis. This was a cross-sectional analysis of data from participants (n = 537) enrolled in the Maternal Vitamin D for Infant Growth trial in Dhaka, Bangladesh. Primary exposures were maternal delivery intact PTH (iPTH) or whole PTH (wPTH) and outcomes were gestational age- and sex-standardized z-scores for birth length (LAZ), weight (WAZ), and head circumference (HCAZ). Hypothesized regulators of PTH included calcium and protein intake, vitamin D, magnesium, fibroblast-like growth factor-23 (FGF23), and C-reactive protein. Maternal iPTH was not associated with birth size in linear regression analyses; however, in path analysis models, every SD increase in log(iPTH) was associated with 0.08SD (95% CI: 0.002, 0.162) higher LAZ. In linear regression and path analysis models, wPTH was positively associated with WAZ. Vitamin D suppressed PTH, while FGF23 was positively associated with PTH. In path analysis models, higher magnesium was negatively associated with LAZ; FGF23 was positively associated and protein intake was negatively associated with LAZ, WAZ, and HCAZ. Higher maternal PTH in late pregnancy is unlikely to contribute to IUGR. Future studies should investigate maternal FGF23, magnesium and protein intake as regulators of fetal growth, particularly in settings where food insecurity and IUGR are public health problems. Bioscientifica Ltd 2021-02-23 /pmc/articles/PMC8052570/ /pubmed/33640873 http://dx.doi.org/10.1530/EC-21-0056 Text en © 2021 The authors https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Research
Qamar, Huma
Perumal, Nandita
Papp, Eszter
Gernand, Alison D
Al Mahmud, Abdullah
Roth, Daniel E
Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
title Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
title_full Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
title_fullStr Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
title_full_unstemmed Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
title_short Higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
title_sort higher maternal parathyroid hormone concentration at delivery is not associated with smaller newborn size
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052570/
https://www.ncbi.nlm.nih.gov/pubmed/33640873
http://dx.doi.org/10.1530/EC-21-0056
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