Intra-patient comparison of physiologic (68)Ga-PSMA-11 and (18)F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay

BACKGROUND: Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing (68)Ga -PSMA-11 and in 96.9% of patients undergoing (18)F-DCFPyL PET/CT examination. We have observed different patterns of ganglion visualization with (18)F-DCFPyL compared...

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Detalles Bibliográficos
Autores principales: Osman, Medhat M., Iravani, Amir, Hofman, Michael S., Hicks, Rodney J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052677/
https://www.ncbi.nlm.nih.gov/pubmed/33863390
http://dx.doi.org/10.1186/s40644-021-00404-8
Descripción
Sumario:BACKGROUND: Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing (68)Ga -PSMA-11 and in 96.9% of patients undergoing (18)F-DCFPyL PET/CT examination. We have observed different patterns of ganglion visualization with (18)F-DCFPyL compared to (68)Ga-PSMA-11. This includes more frequent visualization of cervical and sacral ganglia, which may be attributable to better imaging characteristics with (18)F PET imaging. CASE PRESENTATION: This pictorial essay is to illustrate and compare, in the same patient, various representative cases of (68)Ga-PSMA-11 and (18)F-DCFPyL PET/CT uptake in ganglia at different anatomic locations, with different patterns and distribution of metabolic activity. CONCLUSION: Reading physicians should be aware of the frequently encountered and occasionally different physiologic uptake of (68)Ga-PSMA-11 and (18)F DCFPyL in different ganglia.

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