Cargando…

Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors

The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effects caused by NMs have been observed in recent studies but have not been linked to liver di...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Ting, Kang, Yiyuan, Liu, Jia, Zhang, Yanli, Ou, Lingling, Liu, Xiangning, Lai, Renfa, Shao, Longquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052793/
https://www.ncbi.nlm.nih.gov/pubmed/33863340
http://dx.doi.org/10.1186/s12951-021-00843-2
_version_ 1783679995584970752
author Sun, Ting
Kang, Yiyuan
Liu, Jia
Zhang, Yanli
Ou, Lingling
Liu, Xiangning
Lai, Renfa
Shao, Longquan
author_facet Sun, Ting
Kang, Yiyuan
Liu, Jia
Zhang, Yanli
Ou, Lingling
Liu, Xiangning
Lai, Renfa
Shao, Longquan
author_sort Sun, Ting
collection PubMed
description The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effects caused by NMs have been observed in recent studies but have not been linked to liver disease, and the intrinsic mechanisms are poorly elucidated. Additionally, NMs exhibit varied toxicokinetics and induce enhanced toxic effects in susceptible livers; however, thus far, this issue has not been thoroughly reviewed. This review provides an overview of the toxicokinetics of NMs. We highlight the possibility that NMs induce hepatic diseases, including nonalcoholic steatohepatitis (NASH), fibrosis, liver cancer, and metabolic disorders, and explore the underlying intrinsic mechanisms. Additionally, NM toxicokinetics and the potential induced risks in the livers of susceptible individuals, including subjects with liver disease, obese individuals, aging individuals and individuals of both sexes, are summarized. To understand how NM type affect their toxicity, the influences of the physicochemical and morphological (PCM) properties of NMs on their toxicokinetics and toxicity are also explored. This review provides guidance for further toxicological studies on NMs and will be important for the further development of NMs for applications in various fields. [Image: see text]
format Online
Article
Text
id pubmed-8052793
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-80527932021-04-19 Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors Sun, Ting Kang, Yiyuan Liu, Jia Zhang, Yanli Ou, Lingling Liu, Xiangning Lai, Renfa Shao, Longquan J Nanobiotechnology Review The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effects caused by NMs have been observed in recent studies but have not been linked to liver disease, and the intrinsic mechanisms are poorly elucidated. Additionally, NMs exhibit varied toxicokinetics and induce enhanced toxic effects in susceptible livers; however, thus far, this issue has not been thoroughly reviewed. This review provides an overview of the toxicokinetics of NMs. We highlight the possibility that NMs induce hepatic diseases, including nonalcoholic steatohepatitis (NASH), fibrosis, liver cancer, and metabolic disorders, and explore the underlying intrinsic mechanisms. Additionally, NM toxicokinetics and the potential induced risks in the livers of susceptible individuals, including subjects with liver disease, obese individuals, aging individuals and individuals of both sexes, are summarized. To understand how NM type affect their toxicity, the influences of the physicochemical and morphological (PCM) properties of NMs on their toxicokinetics and toxicity are also explored. This review provides guidance for further toxicological studies on NMs and will be important for the further development of NMs for applications in various fields. [Image: see text] BioMed Central 2021-04-16 /pmc/articles/PMC8052793/ /pubmed/33863340 http://dx.doi.org/10.1186/s12951-021-00843-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Sun, Ting
Kang, Yiyuan
Liu, Jia
Zhang, Yanli
Ou, Lingling
Liu, Xiangning
Lai, Renfa
Shao, Longquan
Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
title Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
title_full Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
title_fullStr Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
title_full_unstemmed Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
title_short Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
title_sort nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052793/
https://www.ncbi.nlm.nih.gov/pubmed/33863340
http://dx.doi.org/10.1186/s12951-021-00843-2
work_keys_str_mv AT sunting nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT kangyiyuan nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT liujia nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT zhangyanli nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT oulingling nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT liuxiangning nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT lairenfa nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors
AT shaolongquan nanomaterialsandhepaticdiseasetoxicokineticsdiseasetypesintrinsicmechanismsliversusceptibilityandinfluencingfactors