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Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients
BACKGROUND: Hyporesponsiveness to erythropoietin stimulating agent (ESA) is associated with poor outcomes in patients with chronic kidney disease. Although ESA hyporesponsiveness and sarcopenia have a common pathophysiological background, clinical evidence linking them is scarce. The purpose of the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052822/ https://www.ncbi.nlm.nih.gov/pubmed/33863297 http://dx.doi.org/10.1186/s12882-021-02346-6 |
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author | Takata, Tomoaki Mae, Yukari Yamada, Kentaro Taniguchi, Sosuke Hamada, Shintaro Yamamoto, Marie Iyama, Takuji Isomoto, Hajime |
author_facet | Takata, Tomoaki Mae, Yukari Yamada, Kentaro Taniguchi, Sosuke Hamada, Shintaro Yamamoto, Marie Iyama, Takuji Isomoto, Hajime |
author_sort | Takata, Tomoaki |
collection | PubMed |
description | BACKGROUND: Hyporesponsiveness to erythropoietin stimulating agent (ESA) is associated with poor outcomes in patients with chronic kidney disease. Although ESA hyporesponsiveness and sarcopenia have a common pathophysiological background, clinical evidence linking them is scarce. The purpose of the study was to investigate the relationship between ESA responsiveness and skeletal muscle mass in hemodialysis patients. METHODS: This cross-sectional study analyzed 70 patients on maintenance hemodialysis who were treated with ESA. ESA responsiveness was evaluated by erythropoietin resistance index (ERI), calculated as a weekly dose of ESA divided by body weight and hemoglobin (IU/kg/week/dL), and a weekly dose of ESA/hemoglobin (IU/week/dL). A dose of ESA is equivalated to epoetin β. Correlations between ESA responsiveness and clinical parameters including skeletal muscle mass were analyzed. RESULTS: Among the 70 patients, ERI was positively correlated to age (p < 0.002) and negatively correlated to height (p < 0.001), body weight (p < 0.001), BMI (p < 0.001), skeletal muscle mass (p < 0.001), transferrin saturation (TSAT) (p = 0.049), and zinc (p = 0.006). In the multiple linear regression analysis, TSAT, zinc, and skeletal muscle mass were associated with ERI and weekly ESA dose/hemoglobin. CONCLUSIONS: Skeletal muscle mass was the independent predictor for ESA responsiveness as well as TSAT and zinc. Sarcopenia is another target for the management of anemia in patients with hemodialysis. |
format | Online Article Text |
id | pubmed-8052822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80528222021-04-19 Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients Takata, Tomoaki Mae, Yukari Yamada, Kentaro Taniguchi, Sosuke Hamada, Shintaro Yamamoto, Marie Iyama, Takuji Isomoto, Hajime BMC Nephrol Research BACKGROUND: Hyporesponsiveness to erythropoietin stimulating agent (ESA) is associated with poor outcomes in patients with chronic kidney disease. Although ESA hyporesponsiveness and sarcopenia have a common pathophysiological background, clinical evidence linking them is scarce. The purpose of the study was to investigate the relationship between ESA responsiveness and skeletal muscle mass in hemodialysis patients. METHODS: This cross-sectional study analyzed 70 patients on maintenance hemodialysis who were treated with ESA. ESA responsiveness was evaluated by erythropoietin resistance index (ERI), calculated as a weekly dose of ESA divided by body weight and hemoglobin (IU/kg/week/dL), and a weekly dose of ESA/hemoglobin (IU/week/dL). A dose of ESA is equivalated to epoetin β. Correlations between ESA responsiveness and clinical parameters including skeletal muscle mass were analyzed. RESULTS: Among the 70 patients, ERI was positively correlated to age (p < 0.002) and negatively correlated to height (p < 0.001), body weight (p < 0.001), BMI (p < 0.001), skeletal muscle mass (p < 0.001), transferrin saturation (TSAT) (p = 0.049), and zinc (p = 0.006). In the multiple linear regression analysis, TSAT, zinc, and skeletal muscle mass were associated with ERI and weekly ESA dose/hemoglobin. CONCLUSIONS: Skeletal muscle mass was the independent predictor for ESA responsiveness as well as TSAT and zinc. Sarcopenia is another target for the management of anemia in patients with hemodialysis. BioMed Central 2021-04-16 /pmc/articles/PMC8052822/ /pubmed/33863297 http://dx.doi.org/10.1186/s12882-021-02346-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Takata, Tomoaki Mae, Yukari Yamada, Kentaro Taniguchi, Sosuke Hamada, Shintaro Yamamoto, Marie Iyama, Takuji Isomoto, Hajime Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
title | Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
title_full | Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
title_fullStr | Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
title_full_unstemmed | Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
title_short | Skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
title_sort | skeletal muscle mass is associated with erythropoietin response in hemodialysis patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052822/ https://www.ncbi.nlm.nih.gov/pubmed/33863297 http://dx.doi.org/10.1186/s12882-021-02346-6 |
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