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Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy

INTRODUCTION: Management of chyluria with initial conservative approach and then using endoscopic sclerotherapy is a mainstay approach. However, a wide range of sclerosants are available with differential success rates and complication rates. This study evaluated the safety and efficacy of a single-...

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Autores principales: Yadav, Praveen Kumar, Swain, Samir, Singh, Anunay, Hasan, Arshad, Haque, Md. Faizul, Kundu, Gaurab, Sharma, Bhupendra Kumar, Hota, Datteswar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052905/
https://www.ncbi.nlm.nih.gov/pubmed/33897162
http://dx.doi.org/10.4103/UA.UA_159_19
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author Yadav, Praveen Kumar
Swain, Samir
Singh, Anunay
Hasan, Arshad
Haque, Md. Faizul
Kundu, Gaurab
Sharma, Bhupendra Kumar
Hota, Datteswar
author_facet Yadav, Praveen Kumar
Swain, Samir
Singh, Anunay
Hasan, Arshad
Haque, Md. Faizul
Kundu, Gaurab
Sharma, Bhupendra Kumar
Hota, Datteswar
author_sort Yadav, Praveen Kumar
collection PubMed
description INTRODUCTION: Management of chyluria with initial conservative approach and then using endoscopic sclerotherapy is a mainstay approach. However, a wide range of sclerosants are available with differential success rates and complication rates. This study evaluated the safety and efficacy of a single-dose instillation of 1% povidone iodine for the treatment of chyluria. MATERIALS AND METHODS: This was a prospective, observational study conducted on patients with chyluria who did not respond to conservative management with dietary restriction and diethylcarbamazine. The site of chyle efflux was identified by cystoscopy. A 6 Fr ureteral stent was inserted into effluxing side, diluted contrast was injected to delineate the pelvicalyceal system and the pyelolymphatic connection (arborization of the pelvicalyceal system), and a single-dose of 1% povidone iodine was instilled. Patients were observed for loin pain, fever, and disappearance of milky urine postinstillation and followed up at intervals of 3 months for a total duration of 1 year. RESULTS: Of a total 50 patients included, 35 were men and 15 were women, with a mean age of 37 years. Pyelolymphatic connections were noted in 48% of the patients. All patients showed an immediate disappearance of milky urine. During 1-year follow-up, 92% of the patients were symptom-free till the last follow-up while only 8% of the patients experienced recurrence of chyluria which were treated with other treatment modalities. The mean duration of recurrence was 8 weeks. CONCLUSION: Single dose of 1% povidone iodine was effective in immediate clearance of milky urine and well tolerated in patients with chyluria during 1-year follow-up.
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spelling pubmed-80529052021-04-23 Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy Yadav, Praveen Kumar Swain, Samir Singh, Anunay Hasan, Arshad Haque, Md. Faizul Kundu, Gaurab Sharma, Bhupendra Kumar Hota, Datteswar Urol Ann Original Article INTRODUCTION: Management of chyluria with initial conservative approach and then using endoscopic sclerotherapy is a mainstay approach. However, a wide range of sclerosants are available with differential success rates and complication rates. This study evaluated the safety and efficacy of a single-dose instillation of 1% povidone iodine for the treatment of chyluria. MATERIALS AND METHODS: This was a prospective, observational study conducted on patients with chyluria who did not respond to conservative management with dietary restriction and diethylcarbamazine. The site of chyle efflux was identified by cystoscopy. A 6 Fr ureteral stent was inserted into effluxing side, diluted contrast was injected to delineate the pelvicalyceal system and the pyelolymphatic connection (arborization of the pelvicalyceal system), and a single-dose of 1% povidone iodine was instilled. Patients were observed for loin pain, fever, and disappearance of milky urine postinstillation and followed up at intervals of 3 months for a total duration of 1 year. RESULTS: Of a total 50 patients included, 35 were men and 15 were women, with a mean age of 37 years. Pyelolymphatic connections were noted in 48% of the patients. All patients showed an immediate disappearance of milky urine. During 1-year follow-up, 92% of the patients were symptom-free till the last follow-up while only 8% of the patients experienced recurrence of chyluria which were treated with other treatment modalities. The mean duration of recurrence was 8 weeks. CONCLUSION: Single dose of 1% povidone iodine was effective in immediate clearance of milky urine and well tolerated in patients with chyluria during 1-year follow-up. Wolters Kluwer - Medknow 2021 2021-01-19 /pmc/articles/PMC8052905/ /pubmed/33897162 http://dx.doi.org/10.4103/UA.UA_159_19 Text en Copyright: © 2021 Urology Annals https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Yadav, Praveen Kumar
Swain, Samir
Singh, Anunay
Hasan, Arshad
Haque, Md. Faizul
Kundu, Gaurab
Sharma, Bhupendra Kumar
Hota, Datteswar
Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy
title Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy
title_full Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy
title_fullStr Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy
title_full_unstemmed Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy
title_short Single-dose instillation of povidone iodine for chyluria: A safe and effective therapy
title_sort single-dose instillation of povidone iodine for chyluria: a safe and effective therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052905/
https://www.ncbi.nlm.nih.gov/pubmed/33897162
http://dx.doi.org/10.4103/UA.UA_159_19
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