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Ultraviolet-induced RNA:DNA hybrids interfere with chromosomal DNA synthesis

Ultraviolet (UV) induces pyrimidine dimers (PDs) in DNA and replication-dependent fragmentation in chromosomes. The rnhAB mutants in Escherichia coli, accumulating R-loops and single DNA-rNs, are generally resistant to DNA damage, but are surprisingly UV-sensitive, even though they remove PDs normal...

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Detalles Bibliográficos
Autores principales:	Kouzminova, Elena A, Kuzminov, Andrei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053090/ https://www.ncbi.nlm.nih.gov/pubmed/33693789 http://dx.doi.org/10.1093/nar/gkab147

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