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Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity

The compact CRISPR/Cas9 system, which can be delivered with their gRNA and a full-length promoter for expression by a single adeno-associated virus (AAV), is a promising platform for therapeutic applications. We previously identified a compact SauriCas9 that displays high activity and requires a sim...

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Detalles Bibliográficos
Autores principales:	Hu, Ziying, Zhang, Chengdong, Wang, Shuai, Gao, Siqi, Wei, Jingjing, Li, Miaomiao, Hou, Linghui, Mao, Huilin, Wei, Yanyan, Qi, Tao, Liu, Hongmao, Liu, Dong, Lan, Feng, Lu, Daru, Wang, Hongyan, Li, Jixi, Wang, Yongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053104/ https://www.ncbi.nlm.nih.gov/pubmed/33721016 http://dx.doi.org/10.1093/nar/gkab148

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