MKRN3-mediated ubiquitination of Poly(A)-binding proteins modulates the stability and translation of GNRH1 mRNA in mammalian puberty

The family of Poly(A)-binding proteins (PABPs) regulates the stability and translation of messenger RNAs (mRNAs). Here we reported that the three members of PABPs, including PABPC1, PABPC3 and PABPC4, were identified as novel substrates for MKRN3, whose deletion or loss-of-function mutations were ge...

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Detalles Bibliográficos
Autores principales: Li, Chuanyin, Han, Tianting, Li, Qingrun, Zhang, Menghuan, Guo, Rong, Yang, Yun, Lu, Wenli, Li, Zhengwei, Peng, Chao, Wu, Ping, Tian, Xiaoxu, Wang, Qinqin, Wang, Yuexiang, Zhou, Vincent, Han, Ziyan, Li, Hecheng, Wang, Feng, Hu, Ronggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053111/
https://www.ncbi.nlm.nih.gov/pubmed/33744966
http://dx.doi.org/10.1093/nar/gkab155

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