MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo

CRISPR-mediated gene activation (CRISPRa) is a promising therapeutic gene editing strategy without inducing DNA double-strand breaks (DSBs). However, in vivo implementation of these CRISPRa systems remains a challenge. Here, we report a compact and robust miniCas9 activator (termed miniCAFE) for in...

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Detalles Bibliográficos
Autores principales: Zhang, Xin, Lv, Sihan, Luo, Zhenhuan, Hu, Yongfei, Peng, Xin, Lv, Jie, Zhao, Shanshan, Feng, Jianqi, Huang, Guanjie, Wan, Qin-Li, Liu, Jun, Huang, Hongxin, Luan, Bing, Wang, Dong, Zhao, Xiaoyang, Lin, Ying, Zhou, Qinghua, Zhang, Zhen-Ning, Rong, Zhili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053112/
https://www.ncbi.nlm.nih.gov/pubmed/33751124
http://dx.doi.org/10.1093/nar/gkab174

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