Cargando…

IL-15 superagonist N-803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34(+) progenitor-derived NK cells

Allogeneic natural killer (NK) cell transfer is a potential immunotherapy to eliminate and control cancer. A promising source are CD34 + hematopoietic progenitor cells (HPCs), since large numbers of cytotoxic NK cells can be generated. Effective boosting of NK cell function can be achieved by interl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Van der Meer, J. M. R., Maas, R. J. A., Guldevall, K., Klarenaar, K., de Jonge, P. K. J. D., Evert, J. S. Hoogstad-van, van der Waart, A. B., Cany, J., Safrit, J. T., Lee, J. H., Wagena, E., Friedl, P., Önfelt, B., Massuger, L. F., Schaap, N. P. M., Jansen, J. H., Hobo, W., Dolstra, H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053152/ https://www.ncbi.nlm.nih.gov/pubmed/33140189 http://dx.doi.org/10.1007/s00262-020-02749-8

Ejemplares similares

Correction to: IL‑15 superagonist N‑803 improves IFNγ production and killing of leukemia and ovarian cancer cells by CD34+ progenitor‑derived NK cells
por: Van der Meer, J. M. R., et al.
Publicado: (2021)

Peritoneal NK cells are responsive to IL-15 and percentages are correlated with outcome in advanced ovarian cancer patients
por: Hoogstad-van Evert, Janneke S., et al.
Publicado: (2018)

Intraperitoneal infusion of ex vivo-cultured allogeneic NK cells in recurrent ovarian carcinoma patients (a phase I study)
por: Hoogstad-van Evert, Janneke, et al.
Publicado: (2019)

TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer
por: Maas, Ralph Ja, et al.
Publicado: (2020)

CD34(+) progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rg(null) mice
por: Van der Meer, Jolien M.R., et al.
Publicado: (2021)

siRNA silencing of PD-1 ligands on dendritic cell vaccines boosts the expansion of minor histocompatibility antigen-specific CD8(+) T cells in NOD/SCID/IL2Rg(null) mice
por: van der Waart, Anniek B., et al.
Publicado: (2015)

Combination of CD8β Depletion and Interleukin-15 Superagonist N-803 Induces Virus Reactivation in Simian-Human Immunodeficiency Virus-Infected, Long-Term ART-Treated Rhesus Macaques
por: McBrien, Julia B., et al.
Publicado: (2020)

Umbilical cord blood CD34(+) progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rg(null) mice
por: Hoogstad-van Evert, Janneke S., et al.
Publicado: (2017)

Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8(+) T cells
por: Mousset, Charlotte M., et al.
Publicado: (2020)

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques
por: Webb, Gabriela M., et al.
Publicado: (2020)

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model
por: Furuya, Hideki, et al.
Publicado: (2019)

CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma
por: Margolin, Kim, et al.
Publicado: (2014)

Complete response to avelumab and IL-15 superagonist N-803 with Abraxane in Merkel cell carcinoma: a case study
por: Drusbosky, Leylah, et al.
Publicado: (2020)

Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rg(null) Mice
por: Cany, Jeannette, et al.
Publicado: (2013)

Combinatorial therapy with an IL-15 superagonist (ALT-803) and anti-PD-L1 mAb augment T cell mediated anti-tumor immunity in mice
por: Johnson, Christopher B, et al.
Publicado: (2014)

Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2(+) pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice
por: Chu, Yaya, et al.
Publicado: (2021)

The IL-15 superagonist ALT-803 enhances anti-CD20 antibody-directed NK cell ADCC and in vivo clearance of B cell lymphomas
por: Rosario, Maximillian, et al.
Publicado: (2014)

The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8(+) T cells into innate-like effector cells with antitumor activity
por: Wong, Hing C, et al.
Publicado: (2013)

Enhanced efficacy of IL-15-based ALT-803 superagonist complex in combination with immune checkpoint inhibitors in hematologic and metastatic mouse tumor models
por: Xu, Wenxin, et al.
Publicado: (2014)

Ex vivo AKT-inhibition facilitates generation of polyfunctional stem cell memory-like CD8(+) T cells for adoptive immunotherapy
por: Mousset, Charlotte M., et al.
Publicado: (2018)

Clinically applicable CD34(+)-derived blood dendritic cell subsets exhibit key subset-specific features and potently boost anti-tumor T and NK cell responses
por: van Eck van der Sluijs, Jesper, et al.
Publicado: (2021)

Human CD34(+)-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8(+) T cell and NK cell responses in vitro and in vivo
por: van Eck van der Sluijs, Jesper, et al.
Publicado: (2023)

Enhanced efficacy of ALT-803, an IL-15-based superagonist complex, in combination with immune checkpoint inhibitors in an orthotopic muscle invasive bladder tumor model in mice
por: Xu, Wenxin, et al.
Publicado: (2015)

An IL-15 Superagonist, ALT-803, Enhances Antibody-Dependent Cell-Mediated Cytotoxicity Elicited by the Monoclonal Antibody NEO-201 Against Human Carcinoma Cells
por: Fantini, Massimo, et al.
Publicado: (2019)

IL15N72D superagonist/IL15Rα-Fc fusion complex (ALT-803) exhibits anti-metastatic activity in murine breast tumor model
por: Kim, Peter S, et al.
Publicado: (2015)

Good manufacturing practice production of CD34(+) progenitor-derived NK cells for adoptive immunotherapy in acute myeloid leukemia
por: de Jonge, P. K. J. D., et al.
Publicado: (2023)

New Roles for Vitamin D Superagonists: From COVID to Cancer
por: Easty, David J., et al.
Publicado: (2021)

Mu-opioid receptor selective superagonists produce prolonged respiratory depression
por: Malcolm, Nicholas J., et al.
Publicado: (2023)

Combination therapy of an IL-15 superagonist complex, ALT-803, and a tumor targeting monoclonal antibody promotes direct antitumor activity and protective vaccinal effect in a syngenic mouse melanoma model
por: Chen, Xiaoyue, et al.
Publicado: (2015)

IL-15 and N-803 for HIV Cure Approaches
por: Howard, J. Natalie, et al.
Publicado: (2023)

Oktett, D. 803
por: Schubert, Franz, 1797-1828
Publicado: (1988)

The Promises of Natural Killer Cell Therapy in Endometriosis
por: Hoogstad-van Evert, Janneke, et al.
Publicado: (2022)

Delayed school progression and mental health problems in adolescence: a population-based study in 10,803 adolescents
por: Tempelaar, Wanda M, et al.
Publicado: (2014)

Are there superagonists for calcium-activated potassium channels?
por: Brown, Brandon M., et al.
Publicado: (2017)

Schedule of experiment R803
por: Jarlskog, G
Publicado: (1973)

Decreased Levels of Circulating IL17-Producing CD161(+)CCR6(+) T Cells Are Associated with Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation
por: van der Waart, Anniek B., et al.
Publicado: (2012)

Oktett F-Dur, D. 803= octet in F major D 803
por: Schubert, Franz 1797-1828
Publicado: (2014)

Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity
por: Weigelin, Bettina, et al.
Publicado: (2021)

Request to extend the measurements of R803 in order to study the production of $\Phi$ and $\Lambda$ at $\Thêta_{cm}$ = $90^{0}$
por: Jarlskog, G, et al.
Publicado: (1974)

Octets D. 803 , D. 72
por: Schubert, Franz, 1797-1828
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_hto071v6mflbjl380jtnebiu26