Cargando…

Upadacitinib in Rheumatoid Arthritis: A Benefit–Risk Assessment Across a Phase III Program

Treating to a target of clinical remission or low disease activity is an important principle for managing rheumatoid arthritis (RA). Despite the availability of biologic disease-modifying antirheumatic drugs (bDMARDs), a substantial proportion of patients with RA do not achieve these treatment targe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conaghan, Philip G., Mysler, Eduardo, Tanaka, Yoshiya, Da Silva-Tillmann, Barbara, Shaw, Tim, Liu, John, Ferguson, Ryan, Enejosa, Jeffrey V., Cohen, Stanley, Nash, Peter, Rigby, William, Burmester, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2021
Materias:	Benefit-Risk Assessment
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053169/ https://www.ncbi.nlm.nih.gov/pubmed/33527177 http://dx.doi.org/10.1007/s40264-020-01036-w

Ejemplares similares

High-Dose Intravenous Iron with Either Ferric Carboxymaltose or Ferric Derisomaltose: A Benefit-Risk Assessment
por: Boots, Johannes M. M., et al.
Publicado: (2022)

Benefit–Risk Analysis of Upadacitinib Compared with Adalimumab in the Treatment of Patients with Moderate-to-Severe Rheumatoid Arthritis
por: Conaghan, Philip, et al.
Publicado: (2021)

Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme
por: Cohen, Stanley B, et al.
Publicado: (2021)

Safety profile of upadacitinib over 15 000 patient-years across rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and atopic dermatitis
por: Burmester, Gerd R, et al.
Publicado: (2023)

Must research benefit human subjects if it is to be permissible?
por: Wikler, Daniel
Publicado: (2017)

For love and money: the need to rethink benefits in HIV cure studies
por: Largent, Emily
Publicado: (2017)

Contractualist reasoning, HIV cure clinical trials, and the moral (ir)relevance of the risk/benefit ratio
por: Kumar, Rahul
Publicado: (2017)

An activist's argument that participant values should guide risk–benefit ratio calculations in HIV cure research
por: Evans, David
Publicado: (2017)

Estimating the effects of Cry1F Bt‐maize pollen on non‐target Lepidoptera using a mathematical model of exposure
por: Perry, Joe N., et al.
Publicado: (2012)

The role of upadacitinib in the treatment of moderate-to-severe active rheumatoid arthritis
por: Avci, Ali Berkant, et al.
Publicado: (2021)

Safety profile of upadacitinib in patients at risk of cardiovascular disease: integrated post hoc analysis of the SELECT phase III rheumatoid arthritis clinical programme
por: Fleischmann, Roy, et al.
Publicado: (2023)

Inhibition of structural joint damage progression with upadacitinib in rheumatoid arthritis: 1-year outcomes from the SELECT phase 3 program
por: Peterfy, Charles G, et al.
Publicado: (2021)

“Why Don’t You Go Into Suburbs? Why Are You Targeting Us?”: Trust and Mistrust in HIV Vaccine Trials in South Africa
por: Thabethe, Siyabonga, et al.
Publicado: (2018)

Construction of a risk assessment model of cardiovascular disease in a rural Chinese hypertensive population based on lasso‐Cox analysis
por: Ouyang, Nanxiang, et al.
Publicado: (2021)

Safety and effectiveness of upadacitinib or adalimumab plus methotrexate in patients with rheumatoid arthritis over 48 weeks with switch to alternate therapy in patients with insufficient response
por: Fleischmann, Roy M, et al.
Publicado: (2019)

The social value of candidate HIV cures: actualism versus possibilism
por: Brown, Regina, et al.
Publicado: (2017)

Incidence and risk factors for herpes zoster in patients with rheumatoid arthritis receiving upadacitinib: a pooled analysis of six phase III clinical trials
por: Winthrop, Kevin L, et al.
Publicado: (2022)

Upadacitinib for rheumatoid arthritis
Publicado: (2020)

Bumblebees can be Exposed to the Herbicide Glyphosate when Foraging
por: Thompson, Linzi J., et al.
Publicado: (2022)

The Safety Profile of Upadacitinib in Patients with Rheumatoid Arthritis in Japan
por: Yamaoka, Kunihiro, et al.
Publicado: (2021)

MACE and VTE across upadacitinib clinical trial programmes in rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis
por: Charles-Schoeman, Christina, et al.
Publicado: (2023)

Impact of initial therapy with upadacitinib or adalimumab on achievement of 48-week treatment goals in patients with rheumatoid arthritis: post hoc analysis of SELECT-COMPARE
por: Mysler, Eduardo, et al.
Publicado: (2022)

Upadacitinib in patients from China, Brazil, and South Korea with rheumatoid arthritis and an inadequate response to conventional therapy
por: Zeng, Xiaofeng, et al.
Publicado: (2021)

Long-term safety and efficacy of upadacitinib or adalimumab in patients with rheumatoid arthritis: results through 3 years from the SELECT-COMPARE study
por: Fleischmann, Roy, et al.
Publicado: (2022)

Upadacitinib improves patient-reported outcomes vs placebo or adalimumab in patients with rheumatoid arthritis: results from SELECT-COMPARE
por: Strand, Vibeke, et al.
Publicado: (2021)

A METHOD TO PREDICT AND UNDERSTAND FISH SURVIVAL UNDER DYNAMIC CHEMICAL STRESS USING STANDARD ECOTOXICITY DATA
por: Ashauer, Roman, et al.
Publicado: (2013)

Assessing Risks to Sea Otters and the Exxon Valdez Oil Spill: New Scenarios, Attributable Risk, and Recovery
por: Harwell, Mark A., et al.
Publicado: (2014)

Quantitative Assessment of Current Risks to Harlequin Ducks in Prince William Sound, Alaska, from the Exxon Valdez Oil Spill
por: Harwell, Mark A., et al.
Publicado: (2012)

Worldwide estimation of river concentrations of any chemical originating from sewage-treatment plants using dilution factors
por: Keller, Virginie DJ, et al.
Publicado: (2014)

Sensitivity of ecological soil-screening levels for metals to exposure model parameterization and toxicity reference values
por: Sample, Bradley E, et al.
Publicado: (2014)

Social involvement, food safety and food security
por: Liuzzo, Gaetano, et al.
Publicado: (2018)

The chemical exposure toxicity space (CETS) model: Displaying exposure time, aqueous and organic concentration, activity, and onset of toxicity
por: Mackay, Donald, et al.
Publicado: (2016)

Food safety objectives, criteria, ranking and hierarchization
por: Liuzzo, Gaetano, et al.
Publicado: (2019)

Cattle Meat and Offal Imported from the United States of America, Canada and Ireland to Japan (Prions)
Publicado: (2020)

A cluster‐randomized study on the Risk Assessment and Management Program for home blood pressure monitoring in an older population with inadequate health literacy
por: Fu, Sau Nga, et al.
Publicado: (2020)

Human and Aquatic Toxicity Potential of Petroleum Biodegradation Metabolite Mixtures in Groundwater from Fuel Release Sites
por: Patterson, Timothy J., et al.
Publicado: (2020)

Screening‐Level Estimates of Environmental Release Rates, Predicted Exposures, and Toxic Pressures of Currently Used Chemicals
por: van de Meent, Dik, et al.
Publicado: (2020)

Mean Species Abundance as a Measure of Ecotoxicological Risk
por: Hoeks, Selwyn, et al.
Publicado: (2020)

Betamethasone (Veterinary Medicinal Products)
Publicado: (2020)

Environmental Risk Assessment for the Active Pharmaceutical Ingredient Mycophenolic Acid in European Surface Waters
por: Straub, Jürg Oliver, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_j1108f0a30c2fgmh9c32424f92