Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacy

BACKGROUND: Associations between mitochondrial genetic abnormalities (variations and copy number, i.e. mtDNAcn, change) and elevated ROS have been reported in cancer compared to normal cells. Since excessive levels of ROS can trigger apoptosis, treating cancer cells with ROS-stimulating agents may e...

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Detalles Bibliográficos
Autores principales: Zaidieh, Tarek, Smith, James R., Ball, Karen E., An, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053302/
https://www.ncbi.nlm.nih.gov/pubmed/33865346
http://dx.doi.org/10.1186/s12885-021-08155-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053302/
https://www.ncbi.nlm.nih.gov/pubmed/33865346
http://dx.doi.org/10.1186/s12885-021-08155-2

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