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Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital

INTRODUCTION: Most post COVID-19 follow-up studies are limited to a follow-up of 3 months. Whether a favorable evolution in lung function and/or radiological abnormalities is to be expected beyond 3 months is uncertain. MATERIALS AND METHODS: We conducted a real-life follow-up study assessing the ev...

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Autores principales: Stylemans, Dimitri, Smet, Jelle, Hanon, Shane, Schuermans, Daniël, Ilsen, Bart, Vandemeulebroucke, Jef, Vanderhelst, Eef, Verbanck, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053365/
https://www.ncbi.nlm.nih.gov/pubmed/33901788
http://dx.doi.org/10.1016/j.rmed.2021.106421
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author Stylemans, Dimitri
Smet, Jelle
Hanon, Shane
Schuermans, Daniël
Ilsen, Bart
Vandemeulebroucke, Jef
Vanderhelst, Eef
Verbanck, Sylvia
author_facet Stylemans, Dimitri
Smet, Jelle
Hanon, Shane
Schuermans, Daniël
Ilsen, Bart
Vandemeulebroucke, Jef
Vanderhelst, Eef
Verbanck, Sylvia
author_sort Stylemans, Dimitri
collection PubMed
description INTRODUCTION: Most post COVID-19 follow-up studies are limited to a follow-up of 3 months. Whether a favorable evolution in lung function and/or radiological abnormalities is to be expected beyond 3 months is uncertain. MATERIALS AND METHODS: We conducted a real-life follow-up study assessing the evolution in lung function, chest CT and ventilation distribution between 10 weeks and 6 months after diagnosis of COVID-19 pneumonia. RESULTS: Seventy-nine patients were assessed at 6 months of whom 63 had chest CT at both follow-up visits and 46 had multiple breath washout testing to obtain lung clearance index (LCI). The study group was divided into a restrictive (n = 39) and a non-restrictive subgroup (n = 40) based on TLC z-score. Restriction was associated with a history of intubation, neuromuscular blockade use and critical illness polyneuropathy. Restriction significantly improved over time, but was not resolved by 6 months (median TLC z-score of −2.2 [IQR: −2.7; −1.5] at 6 months versus −2.7 [IQR: −3.1; −2.1] at 10 weeks). LCI did not evolve between both follow-up visits. Symptoms and chest CT score improved irrespective of restriction. CONCLUSION: We observed a disconnect between the improvement of COVID-19 related symptoms, chest CT lesions, and corresponding lung function. While CT imaging is almost normalized at 6 months, a further reduction of pulmonary restriction may be hoped for beyond 6 months in those patients showing restriction at their first follow-up visit.
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spelling pubmed-80533652021-04-19 Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital Stylemans, Dimitri Smet, Jelle Hanon, Shane Schuermans, Daniël Ilsen, Bart Vandemeulebroucke, Jef Vanderhelst, Eef Verbanck, Sylvia Respir Med Short Communication INTRODUCTION: Most post COVID-19 follow-up studies are limited to a follow-up of 3 months. Whether a favorable evolution in lung function and/or radiological abnormalities is to be expected beyond 3 months is uncertain. MATERIALS AND METHODS: We conducted a real-life follow-up study assessing the evolution in lung function, chest CT and ventilation distribution between 10 weeks and 6 months after diagnosis of COVID-19 pneumonia. RESULTS: Seventy-nine patients were assessed at 6 months of whom 63 had chest CT at both follow-up visits and 46 had multiple breath washout testing to obtain lung clearance index (LCI). The study group was divided into a restrictive (n = 39) and a non-restrictive subgroup (n = 40) based on TLC z-score. Restriction was associated with a history of intubation, neuromuscular blockade use and critical illness polyneuropathy. Restriction significantly improved over time, but was not resolved by 6 months (median TLC z-score of −2.2 [IQR: −2.7; −1.5] at 6 months versus −2.7 [IQR: −3.1; −2.1] at 10 weeks). LCI did not evolve between both follow-up visits. Symptoms and chest CT score improved irrespective of restriction. CONCLUSION: We observed a disconnect between the improvement of COVID-19 related symptoms, chest CT lesions, and corresponding lung function. While CT imaging is almost normalized at 6 months, a further reduction of pulmonary restriction may be hoped for beyond 6 months in those patients showing restriction at their first follow-up visit. Elsevier Ltd. 2021-06 2021-04-18 /pmc/articles/PMC8053365/ /pubmed/33901788 http://dx.doi.org/10.1016/j.rmed.2021.106421 Text en © 2021 Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Stylemans, Dimitri
Smet, Jelle
Hanon, Shane
Schuermans, Daniël
Ilsen, Bart
Vandemeulebroucke, Jef
Vanderhelst, Eef
Verbanck, Sylvia
Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital
title Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital
title_full Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital
title_fullStr Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital
title_full_unstemmed Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital
title_short Evolution of lung function and chest CT 6 months after COVID-19 pneumonia: Real-life data from a Belgian University Hospital
title_sort evolution of lung function and chest ct 6 months after covid-19 pneumonia: real-life data from a belgian university hospital
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8053365/
https://www.ncbi.nlm.nih.gov/pubmed/33901788
http://dx.doi.org/10.1016/j.rmed.2021.106421
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